An improved picture frame construction of a type including a transparent front panel and a corresponding rear panel placed in a congruent relation therewith to enclose a picture or print, and means interconnecting the edges of the juxtaposed panels to maintain them together. In one embodiment of the invention, the device includes a plurality of resilient retaining elements having a channel member gripping the edges of the panels, and a hooked member engaging circular openings in the rear panel, all of which may be formed as a single stamping operation. Release of the retaining elements is accomplished by lifting the hooked member from the engagement with the opening, using a manually engageable tab provided for that purpose. In a modified form of the embodiment, a separate opening-forming member is adhesively secured to the exposed surface of the rear panel. In a second embodiment, pairs of opposed retaining members are resiliently linked by a ball chain to provide an equivalent result.