Sandra Whaley Bishnoi

US Patent:

20080176212, Jul 24, 2008

Filed:

Jun 13, 2007

Appl. No.:

11/762430

Inventors:

Nancy J. Halas - Houston TX, US
Don H. Johnson - Houston TX, US
Sandra Whaley Bishnoi - Wilmette IL, US
Carly S. Levin - Houston TX, US
Christopher John Rozell - Houston TX, US
Bruce R. Johnson - Houston TX, US

Assignee:

William Marsh Rice University - Houston TX

International Classification:

C12Q 1/00
G01N 31/16
G01J 3/00

US Classification:

435 4, 436163, 356300, 356301, 977920

Abstract:

A composition comprising a nanoparticle and at least one adsorbate associated with the nanoparticle, wherein the adsorbate displays at least one chemically responsive optical property. A method comprising associating an adsorbate with a nanoparticle, wherein the nanoparticle comprises a shell surrounding a core material with a lower conductivity than the shell material and the adsorbate displays at least one chemically responsive optical property, and engineering the nanoparticle to enhance the optical property of the adsorbate. A method comprising determining an optical response of an adsorbate associated with a nanoparticle as a function of a chemical parameter, and parameterizing the optical response to produce a one-dimensional representation of at least a portion of a spectral window of the optical response in a high dimensional vector space.

US Patent:

20200164072, May 28, 2020

Filed:

Oct 7, 2019

Appl. No.:

16/595060

Inventors:

- Houston TX, US
Oara Neumann - Houston TX, US
Amanda M. Goodman - Houston TX, US
Sandra W. Bishnoi - Houston TX, US
Susan E. Clare - Houston TX, US

Assignee:

William Marsh Rice University - Houston TX

International Classification:

A61K 41/00
A61K 47/26
A61K 31/498
A61K 9/51
A61K 38/19
A61K 31/713
A61K 47/42
A61K 9/127
A61K 31/337
A61K 38/38

Abstract:

A nanosample capable of near-infrared light-triggered release of therapeutic molecules. The nanosample includes a plurality of nanocomplexes. Each of the nanocomplexes includes a nanoshell; a host molecule linked to the nanoshell; and a guest molecule linked to the host molecule. The nanoshell includes a shell. The nanocomplex has a plasmon resonance wavelength. When irradiated with electromagnetic radiation of the plasmon resonance wavelength, plasmon resonance of the nanocomplex releases the guest molecule. The nanoshell may also include a core, where the shell surrounds the core. The nanoshell may be a nanomatryoshka. A link between the nanoshell and the host molecule may be a gold-thiol interaction. The shell may include at least one metal, such as gold or silver. The core may be a liposome and/or silica. The host molecule may be: synthetic polymers, biopolymers, polynucleotides, nucleic acids, polypeptides, polysaccharides, polyterpenes, lipids, aptamers, and/or proteins. The guest molecule may be: pharmaceutical molecules, biopharmaceutical molecules, oligonucleotides, nucleic acids, dye molecules, and/or imaging contrast agents. The host molecule may be: aptamer, single-stranded DNA, double-stranded DNA, and/or human serum albumin. The guest molecule may be: docetaxel, lapatinib, and/or tumor necrosis factor alpha. The plasmon resonance wavelength may be in a near-infrared (NIR) water window.

US Patent:

20180008730, Jan 11, 2018

Filed:

Sep 15, 2017

Appl. No.:

15/706429

Inventors:

- Houston TX, US
Ciceron Ayala-Orozco - Stafford TX, US
Sandra Bishnoi - Houston TX, US
Luke Henderson - Houston TX, US
Oara Neumann - Houston TX, US
Robia Pautler - Houston TX, US

Assignee:

William Marsh Rice University - Houston TX

International Classification:

A61K 49/18
C23C 18/16
C23C 18/31
H01B 3/02

Abstract:

A Magnetic Resonance Imaging (MRI) enhancement agent includes a plurality of particles, each particle including: a metal core; a dielectric shell disposed on the metal core comprising at least one MRI contrast agent; and a metal shell disposed on the exterior surface of the dielectric shell that encapsulates the dielectric shell.

US Patent:

20160038618, Feb 11, 2016

Filed:

Aug 11, 2015

Appl. No.:

14/823891

Inventors:

- Houston TX, US
Ciceron Ayala-Orozco - Stafford TX, US
Sandra Bishnoi - Houston TX, US

International Classification:

A61K 49/18

Abstract:

A magnetic resonance imaging enhancement agent includes a plurality of particles. Each particle including a metal core; a dielectric shell disposed on the metal core including water and at least one MRI contrast agent; and a metal shell disposed on the exterior surface of the dielectric shell that encapsulates the dielectric shell.