Sandra Lynn Burke

US Patent:

7357942, Apr 15, 2008

Filed:

Aug 15, 2006

Appl. No.:

11/464676

Inventors:

Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Matthew Mack - Chicago IL, US
John L. Toner - Libertyville IL, US

Assignee:

Abbott Laboratories - Abott Park IL

International Classification:

A61F 2/02
A61K 31/44
A61K 31/335

US Classification:

424423, 514291, 514449

Abstract:

A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

US Patent:

7378105, May 27, 2008

Filed:

Aug 15, 2006

Appl. No.:

11/464659

Inventors:

Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Matthew Mack - Chicago IL, US
John L. Toner - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61F 2/00
A61K 31/44

US Classification:

424423, 514291

Abstract:

A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

US Patent:

7399480, Jul 15, 2008

Filed:

Oct 29, 2004

Appl. No.:

10/977288

Inventors:

Karl W. Mollison - Arlington Heights IL, US
Angela M. LeCaptain - Oak Creek WI, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Peter J. Tarcha - Lake Villa IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61F 2/00

US Classification:

424423

Abstract:

A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,.

US Patent:

7455853, Nov 25, 2008

Filed:

Sep 10, 2002

Appl. No.:

10/488815

Inventors:

Karl W. Mollison - Arlington Heights IL, US
Angela M. LeCaptain - Oak Creek WI, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Peter J. Tarcha - Lake Villa IL, US
Yen-Chih J. Chen - Evanston IL, US
John L. Toner - Libertyville IL, US

Assignee:

Abbott Cardiovascular Systems Inc. - Santa Clara CA

International Classification:

A61F 2/00
A01N 43/42

US Classification:

424423, 514291, 514283

Abstract:

A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

US Patent:

8057813, Nov 15, 2011

Filed:

Mar 18, 2005

Appl. No.:

11/084172

Inventors:

John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Randolf von Oepen - Los Altos CA, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61F 13/00

US Classification:

424422, 427 224, 427 21, 4274211, 427424

Abstract:

Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

US Patent:

8057816, Nov 15, 2011

Filed:

Oct 12, 2006

Appl. No.:

11/548974

Inventors:

John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Matthew Mack - Chicago IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61F 2/00
A01N 63/00
A01N 43/42
A01N 43/04
A61K 39/395
A61K 31/44
A61K 31/56
A61K 31/727
A61K 31/355

US Classification:

424423, 514291, 514171, 514 34, 514 56, 514449, 424 9463, 4241301, 4241411

Abstract:

Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

US Patent:

8153150, Apr 10, 2012

Filed:

Jun 20, 2008

Appl. No.:

12/143689

Inventors:

Karl W. Mollison - Arlington Heights IL, US
Angela M. LeCaptain - Oak Creek WI, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Peter J. Tarcha - Lake Villa IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61F 2/00

US Classification:

424426, 424422, 604 9601, 623 111, 623 112, 623 113, 623 115, 623 123, 623 125, 623 142

Abstract:

A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,.

US Patent:

8257726, Sep 4, 2012

Filed:

Aug 15, 2006

Appl. No.:

11/464667

Inventors:

Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Gurnee IL, US
Matthew Mack - Chicago IL, US
John L. Toner - Libertyville IL, US

Assignee:

Abbott Laboratories - Abott Park IL

International Classification:

A61F 2/00
A61K 31/44
A61K 31/335

US Classification:

424423, 514291, 514449

Abstract:

A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.