Sandra Kay Sigmund

US Patent:

55501184, Aug 27, 1996

Filed:

Jan 31, 1994

Appl. No.:

8/189213

Inventors:

Joseph A. Jakubowski - Indianapolis IN
Alan D. Palkowitz - Carmel IN
Sandra K. Sigmund - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3144
A61K 31675
C07F 958
C07D47104

US Classification:

514 89

Abstract:

Selected acid functional polyhydronorharman type derivatives effective as thromboxane synthase inhibitors having the formula: ##STR1## where R. sub. 1 and R. sub. 2 are monovalent radicals, --(L. sub. a)-- is a linking group of 4 to 8 chain atoms, and A is an acidic group.

US Patent:

48269921, May 2, 1989

Filed:

Nov 24, 1986

Appl. No.:

6/934054

Inventors:

Louis N. Jungheim - Indianapolis IN
Sandra K. Sigmund - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D23100

US Classification:

548359

Abstract:

2,3-(Dihydro) bicyclic pyrazolidinones are intermediates for bicyclic pyrazolidinone antimicrobials.

US Patent:

6251928, Jun 26, 2001

Filed:

Mar 16, 1994

Appl. No.:

8/213873

Inventors:

Jill A. Panetta - Zionsville IN
Michael L. Phillips - Indianapolis IN
Jon K. Reel - Carmel IN
John K. Shadle - Fishers IN
Sandra K. Sigmund - Indianapolis IN
Richard L. Simon - Greenwood IN
Celia A. Whitesitt - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31427

US Classification:

514369

Abstract:

This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with. beta. -amyloid peptide. This invention further provides methods of treating or preventing Alzheimer's Disease which comprises administering to a mammal in need thereof an effective amount of one or more of the benzylidene rhodanines of the present invention.

US Patent:

54687578, Nov 21, 1995

Filed:

Jan 31, 1994

Appl. No.:

8/189212

Inventors:

Joseph A. Jakubowski - Indianapolis IN
Alan D. Palkowitz - Carmel IN
Sandra K. Sigmund - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31435
C07D47104

US Classification:

514300

Abstract:

Selected acid functional 6-azaindole type derivatives effective as thromboxane synthase inhibitors having the formula (II): ##STR1## where n is an integer from zero to 3, m is an integer from zero to 2, R. sub. 1 and R. sub. 2 are monovalent radicals, --(L. sub. a)-- is a linking group of 4 to 8 chain atoms, and A is an acidic group.

US Patent:

48207233, Apr 11, 1989

Filed:

Aug 14, 1987

Appl. No.:

7/085588

Inventors:

Winston S. Marshall - Bargersville IN
Sandra K. Sigmund - Carmel IN
Celia A. Whitesitt - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D25704
C07D40306
A61K 3141

US Classification:

514381

Abstract:

The instant invention provides disubstituted tetrazoles that antagonizes the effect of leukotrienes C. sub. 4, D. sub. 4 or E. sub. 4 or any combination thereof in selected tissues. The disubstituted tetrazoles are used in pharmaceutical formulations and methods of treatment of conditions caused by excessive release or production of leukotrienes C. sub. 4, D. sub. 4 or E. sub. 4 or any combination thereof. Such conditions include an immediate hypersensitivity reaction of the type represented by asthma, or by shock or other adverse cardiovascular effects.

US Patent:

49407180, Jul 10, 1990

Filed:

Oct 2, 1989

Appl. No.:

7/418782

Inventors:

Charles J. Barnett - Indianapolis IN
Richard E. Holmes - Indianapolis IN
Louis N. Jungheim - Indianapolis IN
Sandra K. Sigmund - Carmel IN
Robert J. Ternansky - Noblesville IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31425
A61K 31415
C07D23100
C07D41312

US Classification:

514370

Abstract:

7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.

US Patent:

49027077, Feb 20, 1990

Filed:

Apr 30, 1985

Appl. No.:

6/729009

Inventors:

Louis N. Jungheim - Indianapolis IN
Sandra K. Sigmund - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A01N 4356
A61K 31415
C07D23100

US Classification:

514405

Abstract:

Bicyclic pyrazolidinones which have antimicrobial and/or herbicidal properties are discussed. The use of these compounds in pharmaceutical compositions, herbicidal compositions, and methods for treating bacterial infections and controlling undesired plants is set forth.

US Patent:

47772999, Oct 11, 1988

Filed:

Jan 11, 1988

Appl. No.:

7/142112

Inventors:

Winston S. Marshall - Bargersville IN
Sandra K. Sigmund - Indianapolis IN
Celia A. Whitesitt - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C 4500

US Classification:

568319

Abstract:

1,3-Dialkylbenzenes are acylated and deprotected in a mixture of acetic or propionic acid and hydrobromic acid. The dihydroxyphenones thus produced are intermediates in the synthesis of leukotriene antagonists.