Sarah K Baxter

US Patent:

20190000493, Jan 3, 2019

Filed:

Nov 23, 2015

Appl. No.:

15/534549

Inventors:

- EINDHOVEN, NL
Sonia Souza - Bothell WA, US
Jeffry Earl Powers - Bainbridge Island WA, US
William Tao Shi - Wakefield MA, US
Terrence James Sweeney - Redmond WA, US
Sarah Rhoades Baxter - Hansville WA, US

International Classification:

A61B 17/225
A61B 8/08
A61B 34/00

Abstract:

An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller () configured for adjusting, based on an estimate of thickness of a temporal bone () in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02) to 1.1×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

US Patent:

20140148361, May 29, 2014

Filed:

Jun 7, 2011

Appl. No.:

13/702972

Inventors:

Barry L. Stoddard - Bellevue WA, US
Abigail Rose Lambert - Kenmore WA, US
Ryo Takeuchi - Seattle WA, US
Andrew M. Scharenberg - Seattle WA, US
Sarah Katherine Baxter - Seattle WA, US

International Classification:

C12N 15/10

US Classification:

506 11

Abstract:

The present disclosure provides compositions and methods for producing and expressing variant or engineered I-OnuI endonucleases, variant or engineered I-OnuI homologues, and hybrids of two I-OnuI or I-OnuI homologue domains that have a target site altered from the wild-type. A method for selecting a variant or engineered I-OnuI endonuclease, I-OnuI endonuclease homologue, and a hybrid of two I-OnuI or I-OnuI homologue domains that have a target site altered from the wild-type and directed to a site within a gene of interest is also provided. In addition, the present disclosure provides the crystal structure of the I-OnuI and I-LtrI endonucleases; the specificity profiles for both endonuclease for DNA binding and cleavage; the identity of amino acid residue positions in the I-OnuI and I-LtrI protein scaffold that determine DNA recognition specificity; methods for determining amino acid substitutions at those positions that alter DNA cleavage specificity; methods for the complete redesign of the DNA cleavage specificity of I-OnuI and its homologues for recognition and cleavage of a human gene of interest; and the relationship of the amino acid sequence, structure and specificity of I-OnuI to a collection of identifiable I-OnuI endonuclease homologues.