Sarah Sim Park

US Patent:

D670140, Nov 6, 2012

Filed:

Jan 21, 2012

Appl. No.:

29/411499

Inventors:

Daniel Kavanaugh - Leawood KS, US
Christopher Hawker - Columbus OH, US
Jessica Moreland - Columbus OH, US
Sarah Park - Dublin OH, US

Assignee:

Evriholder Products, LLC - Anaheim CA

International Classification:

0704

US Classification:

D 7676

US Patent:

20210340692, Nov 4, 2021

Filed:

Sep 25, 2019

Appl. No.:

17/272139

Inventors:

- Evanston IL, US
Taegon Oh - Evanston IL, US
Sarah S. Park - Evanston IL, US

International Classification:

C30B 29/02
C30B 29/58
C30B 7/08

Abstract:

A post-synthetic method for stabilizing colloidal crystals programmed from nucleic acid is disclosed herein. In some embodiments, the method relies on Ag ions to stabilize the particle-connecting nucleic acid duplexes within the crystal lattice, essentially transforming them from loosely bound structures to ones with very strong interparticle links. In some embodiments, the nucleic acid is DNA. Such crystals do not dissociate as a function of temperature like normal DNA or DNA-interconnected colloidal crystals, and they can be moved from water to organic media or the solid state, and stay intact. The Ag-stabilization of the nucleic acid (e.g., DNA) bonds is accompanied by a nondestructive contraction of the lattice, and both the stabilization and contraction are reversible with the chemical extraction of the Ag ions, e.g., by AgCl precipitation with NaCl.