Saul Kit

US Patent:

48246670, Apr 25, 1989

Filed:

Jul 28, 1987

Appl. No.:

7/078601

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

A61K 3912

US Classification:

424 89

Abstract:

Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.

US Patent:

49992961, Mar 12, 1991

Filed:

Apr 29, 1986

Appl. No.:

6/857703

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

C12P 2100
C12N 1500
C12N 700

US Classification:

4352351

Abstract:

The present invention relates to pseudorabies viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against pseudorabies containing the same, and methods for the production and use of the same. The present invention also relates to pseudorabies virus based viral vectors for the coexpression of foreign genes.

US Patent:

52926532, Mar 8, 1994

Filed:

Sep 27, 1989

Appl. No.:

7/413040

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

C12N 700
C12N 1500

US Classification:

4352351

Abstract:

The present invention relates to Equine Herpesvirus Type 1 mutants which fail to produce any functional thymidine kinase as a result of a deletion and/or insertion in the EHV-1 thymidine kinase gene.

US Patent:

47538848, Jun 28, 1988

Filed:

Sep 10, 1987

Appl. No.:

7/094998

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

C12N 704
C12N 1500
C12P 2100
A61K 39245

US Classification:

435235

Abstract:

The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.

US Patent:

47030119, Oct 27, 1987

Filed:

Nov 12, 1985

Appl. No.:

6/796840

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

C12N 704
C12N 1500
A61K 3912

US Classification:

435236

Abstract:

Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.

US Patent:

56018169, Feb 11, 1997

Filed:

Feb 22, 1995

Appl. No.:

8/392406

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

Novagene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

A61K 39265
A61K 3576
C12N 700
C12N 701

US Classification:

424 932

Abstract:

The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. The present invention also relates to infectious bovine rhinotracheitis-based viral vectors useful for the coexpression of foreign genes.

US Patent:

47118504, Dec 8, 1987

Filed:

Jan 28, 1986

Appl. No.:

6/823439

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX

Assignee:

NovaGene, Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

C12N 700
A61K 39205

US Classification:

435235

Abstract:

The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.

US Patent:

51281295, Jul 7, 1992

Filed:

Oct 1, 1990

Appl. No.:

7/591999

Inventors:

Malon Kit - Houston TX
Saul Kit - Houston TX
Haruki Otsuka - Houston TX

Assignee:

Novagene Inc. - Houston TX
Baylor College of Medicine - Houston TX

International Classification:

A61K 39265
A61K 3576
C12N 700
C12N 701

US Classification:

424 89

Abstract:

Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.