Scott A Gilbert

US Patent:

7011649, Mar 14, 2006

Filed:

Nov 8, 2002

Appl. No.:

10/291312

Inventors:

Pedro E. De La Serna - San Jose CA, US
Scott J. Gilbert - Menlo Park CA, US

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61M 5/32

US Classification:

604197

Abstract:

The present invention provides a syringe cartridge that is sufficiently robust to be used in autoinjectors that generate injection forces sufficient to deliver viscous medicaments. The syringe cartridge of the present invention includes a syringe, a bias mechanism, and a casing. The casing of the syringe cartridge of the present invention includes a collapsible portion and a fixed portion. Advantageously, the collapsible portion of the casing collapses within the fixed portion of the casing as the syringe is driven through its stroke within the syringe cartridge. As the collapsible portion collapses within the fixed portion, the length of the syringe cartridge is effectively reduced, which, in turn, allows the use of a shorter plunger and thereby facilitates the construction of a more compact autoinjector.

US Patent:

7014636, Mar 21, 2006

Filed:

Nov 21, 2002

Appl. No.:

10/302104

Inventors:

Scott Jay Gilbert - Menlo Park CA, US

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61K 9/22

US Classification:

6048921, 424422

Abstract:

An implantable osmotically driven delivery system having a dynamic, two-way valve and a self-adjusting, variable geometry fluid flow channel. As pressure within the agent delivery system increases, the fluid channel narrows, thereby restricting flow. At exceptionally high pressures, the valve can be designed to close altogether at the orifice or delivery end, or it can provide a minimal leak path so that a maximum fluid flow is never exceeded. At zero or very low pressures, the valve will close completely at the beneficial agent reservoir end, isolating the beneficial agent formulation from external fluid infiltration and thereby eliminating diffusion of external fluid into the beneficial agent formulation.

US Patent:

7097634, Aug 29, 2006

Filed:

Jul 31, 2003

Appl. No.:

10/632943

Inventors:

Scott Gilbert - Menlo Park CA, US

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61M 37/00

US Classification:

604150, 604135, 604197, 604110

Abstract:

The present invention includes an automatic injection device that reliably provides automatic needle retraction even when manufactured with part and assembly tolerances typical of low-cost and high-volume manufacturing processes. The injector of the present invention includes a body, a syringe cartridge, a drive mechanism, and a bias mechanism. The drive mechanism includes an energy source, a drive member, and a compound plunger with a releasable coupling. Significantly, the compound plunger included in the drive mechanism is designed to ensure needle retraction occurs after the automatic injection device has delivered the desired dose of medicament. Moreover, the design of the compound plunger included in the injector of the present invention can compensate for part and assembly tolerances typical of low-cost, high volume manufacturing processes, enabling the fabrication of a low cost automatic injection device providing reliable automatic needle retraction.

US Patent:

7163688, Jan 16, 2007

Filed:

Jun 18, 2002

Appl. No.:

10/173992

Inventors:

John R. Peery - Stanford CA, US
Scott J. Gilbert - Menlo Park CA, US
James E. Brown - Los Gatos CA, US

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61F 13/00
A61F 2/00
A61K 9/48

US Classification:

424422, 424424, 424425, 424451, 424454

Abstract:

An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i. e. , die-cutting, stamping or otherwise cutting to shape) to provide a uniform nonribbed membrane material. The capsule also includes a membrane material-retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.

US Patent:

7316680, Jan 8, 2008

Filed:

Sep 27, 2005

Appl. No.:

11/237489

Inventors:

Scott Jay Gilbert - Menlo Park CA, US

Assignee:

Intarcia Therapeutics, Inc. - Emeryville CA

International Classification:

A61K 9/22

US Classification:

6048921

Abstract:

An implantable osmotically driven delivery system having a dynamic, two-way valve and a self-adjusting, variable geometry fluid flow channel. As pressure within the agent delivery system increases, the fluid channel narrows, thereby restricting flow. At exceptionally high pressures, the valve can be designed to close altogether at the orifice or delivery end, or it can provide a minimal leak path so that a maximum fluid flow is never exceeded. At zero or very low pressures, the valve will close completely at the beneficial agent reservoir end, isolating the beneficial agent formulation from external fluid infiltration and thereby eliminating diffusion of external fluid into the beneficial agent formulation.

US Patent:

7381201, Jun 3, 2008

Filed:

Jun 24, 2003

Appl. No.:

10/603513

Inventors:

Scott Gilbert - Menlo Park CA, US
Pedro de la Sema - San Jose CA, US

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61M 5/00

US Classification:

604181

Abstract:

The present invention provides a reusable spring driven autoinjector. The drive mechanism of the autoinjector of the present invention includes one or more drive springs formed of a shape memory alloy. Therefore, by alternating the shape memory alloy forming the one or more drive springs between austenite phase before an injection and a martensite phase after injection, the reusable autoinjector of the present invention is capable of providing an injection force that is higher than the compressive force required to cock the drive mechanism in preparation for a subsequent injection operation.

US Patent:

7654983, Feb 2, 2010

Filed:

Nov 8, 2002

Appl. No.:

10/290914

Inventors:

Pedro E. De La Sema - San Jose CA, US
Scott J. Gilbert - Menlo Park CA, US

Assignee:

Johnson and Johnson Vision Care, Inc. - Jacksonville FL

International Classification:

A61M 37/00

US Classification:

604141, 604506

Abstract:

The present invention provides a pneumatic injector that includes a pressurized gas source, an actuator, a driver, and a dispenser. The dispenser of the injector includes a reservoir for containing a desired amount of a chosen medicament and a needle, such as a hypodermic needle, suitable for subcutaneous, intramuscular, or intra-articular delivery of the chosen medicament. The actuator actuates the transmission of pressurized gas from the pressurized gas source to the driver, and as pressurized gas is delivered to the driver, the driver exerts at least an injection force. The injection force is of sufficient magnitude to expel a chosen medicament through the needle of the dispenser within a desired amount of time. Advantageously, the design of the injector of the present invention is extremely flexible, allowing the injector to be designed to deliver a wide range of medicaments in virtually any human or veterinary context calling for the injection of the subcutaneous, intramuscular, or intra-articular injection of medicament.

US Patent:

8591457, Nov 26, 2013

Filed:

Aug 10, 2005

Appl. No.:

11/200971

Inventors:

Scott J. Gilbert - Menlo Park CA, US

Assignee:

Alza Corporation - Vacaville CA

International Classification:

A61M 5/30

US Classification:

604 70

Abstract:

A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.