Scott Christopher Long

US Patent:

6664255, Dec 16, 2003

Filed:

May 18, 2000

Appl. No.:

09/574752

Inventors:

Michael South - St. Louis MO
John J. Parlow - Arnold MO
Darin E. Jones - Ballwin MO
Brenda Case - St. Louis MO
Tom Dice - St. Charles MO
Richard Lindmark - Kirkwood MO
Michael J. Hayes - St. Louis MO
Melvin L. Rueppel - St. Louis MO
Horng-Chih Huang - Chesterfield MO
Wei Huang - Wildwood MO
Scott A. Long - Ballwin MO
Matthew Mahoney - St. Peters MO
William L. Neumann - St. Louis MO
David Reitz - Chesterfield MO
John I. Trujillo - Creve Coeur MO
Ching-Cheng Wang - Wildwood MO
Rhonda Wood - Maryland Heights MO
Qingping Zeng - Ballwin MO
Rick Fenton - Collinsville IL
Gary W. Franklin - Godfrey IL
Carrie Kusturin - Edwardsville IL

Assignee:

Pharmacia Corporation - Chicago IL

International Classification:

C07D24120

US Classification:

5142358, 544405, 544237, 544295, 544120, 51425505, 514248

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

US Patent:

6908919, Jun 21, 2005

Filed:

Jul 15, 2002

Appl. No.:

10/195573

Inventors:

Michael S. South - St. Louis MO, US
Brenda L. Case - St. Louis MO, US
Thomas A. Dice - St. Charles MO, US
Ricky L. Fenton - Collinsville IL, US
Gary W. Franklin - Godfrey IL, US
Michael J. Hayes - St. Louis MO, US
Horng-Chih Huang - Chesterfield MO, US
Wei Huang - Wildwood MO, US
Darin E. Jones - Ballwin MO, US
Carrie L. Kusturin - Edwardsville IL, US
Richard J. Lindmark - St. Louis MO, US
Scott A. Long - Ballwin MO, US
William L. Neumann - St. Louis MO, US
David B. Reitz - Chesterfield MO, US
John I. Trujillo - St. Louis MO, US
Ching-Cheng Wang - Wildwood MO, US
Rhonda Wood - Maryland Heights MO, US
Qingping Zeng - Ballwin MO, US
Matthew W. Mahoney - St. Peters MO, US
John J. Parlow - Arnold MO, US
Melvin L. Rueppel - St. Louis MO, US

Assignee:

Pharmacia Corporation - Chicago IL

International Classification:

C07D241/20
C07D417/12
C07D401/12
A61K031/495
A61P007/02

US Classification:

5142358, 51425505, 514248, 544405, 544237, 544295, 544120

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

US Patent:

7119094, Oct 10, 2006

Filed:

Nov 20, 2000

Appl. No.:

10/276174

Inventors:

Michael S. South - St. Louis MO, US
John J. Parlow - Arnold MO, US
Darin E. Jones - Ballwin MO, US
Brenda Case - St. Louis MO, US
Tom Dice - St. Charles MO, US
Richard Lindmark - Kirkwood MO, US
Michael J. Hayes - St. Louis MO, US
Melvin L. Rueppel - St. Louis MO, US
Rick Fenton - Collinsville IL, US
Gary W. Franklin - Godfrey IL, US
Horng-Chih Huang - Chesterfield MO, US
Wei Huang - Wildwood MO, US
Carrie Kusturin - Edwardsville IL, US
Scott A. Long - Ballwin MO, US
William L. Neumann - St. Louis MO, US
David B. Reitz - Chesterfield MO, US
John I. Trujillo - Creve Coeur MO, US
Ching-Cheng Wang - Wildwood MO, US
Rhonda Wood - Maryland Heights MO, US
Qingping Zeng - Ballwin MO, US
Matthew W. Mahoney - St. Peters MO, US

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31/4965
C07D 241/02

US Classification:

51425506, 544408

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

US Patent:

20040102448, May 27, 2004

Filed:

Oct 23, 2003

Appl. No.:

10/691958

Inventors:

Michael South - St. Louis MO, US
John Parlow - Arnold MO, US
Darin Jones - Ballwin MO, US
Brenda Case - St. Louis MO, US
Tom Dice - St. Charles MO, US
Richard Lindmark - Kirkwood MO, US
Michael Hayes - St. Louis MO, US
Melvin Rueppel - St. Louis MO, US
Horng-Chih Huang - Chesterfield MO, US
Wei Huang - Wildwood MO, US
Scott Long - Ballwin MO, US
Matthew Mahoney - St. Peters MO, US
William Neumann - Ballwin MO, US
David Reitz - Chesterfield MO, US
John Trujillo - St. Peters MO, US
Ching-Cheng Wang - Wildwood MO, US
Rhonda Wood - Maryland Heights MO, US
Qingping Zeng - Thousand Oaks CA, US
Rick Fenton - Collinsville IL, US
Gary Franklin - Godfrey IL, US
Carrie Kusturin - Edwardsville IL, US

Assignee:

Pharmacia Corporation

International Classification:

A61K031/4965
A61K031/497
C 07D 4 3/02

US Classification:

514/252100, 514/255050, 544/405000, 544/408000

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of dirombotic conditions including coronary artery and cerebrovascular diseases.

US Patent:

20050043313, Feb 24, 2005

Filed:

Sep 14, 2004

Appl. No.:

10/940693

Inventors:

Michael South - St. Louis MO, US
Brenda Case - St. Louis MO, US
Thomas Dice - St. Charles MO, US
Ricky Fenton - Collinsville IL, US
Gary Franklin - Godfrey IL, US
Michael Hayes - St. Louis MO, US
Horng-Chih Huang - Chesterfield MO, US
Wei Huang - Wildwood MO, US
Darin Jones - Ballwin MO, US
Carrie Kusturin - Edwardsville IL, US
Richard Lindmark - St. Louis MO, US
Scott Long - Ballwin MO, US
William Neumann - St. Louis MO, US
David Reitz - Chesterfield MO, US
John Trujillo - St. Louis MO, US
Ching-Cheng Wang - Wildwood MO, US
Rhonda Wood - Maryland Heights MO, US
Qingping Zeng - Ballwin MO, US
Matthew Mahoney - St. Peters MO, US
John Parlow - Arnold MO, US
Melvin Rueppel - St. Louis MO, US

International Classification:

A61K031/4965
C07D043/02
A61K031/497

US Classification:

514252100, 514255050, 544405000

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.