Scott Lundahl - Lexington MA Rebecca Kozodoy - Randolph MA Ronald Carroll - Hingham MA Elton Leppelmeier - Highland Height OH
Assignee:
Dusa Pharmaceuticals, Inc. - Toronto
International Classification:
A61N 506
US Classification:
607 88, 607 91
Abstract:
An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the event of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity.
Scott Lundahl - Lexington MA, US Rebecca Kozodoy - Randolph MA, US Ronald Carroll - Hingham MA, US Elton Leppelmeier - Highland Heights OH, US
Assignee:
Dusa Pharmaceuticals, Inc. - Toronto
International Classification:
H01J 61/44 A61B 5/00
US Classification:
313485, 600476, 607 91
Abstract:
An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the event of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity.
Method Of Photodynamically Diagnosing Or Treating A Contoured Surface
Scott Lundahl - Lexington MA, US Rebecca Kozodoy - Randolph MA, US Ronald Carroll - Hingham MA, US Elton Leppelmeier - Highland Height OH, US
Assignee:
DUSA Pharmaceuticals, Inc. - Wilmington DE
International Classification:
H01J 61/44 A61B 5/00
US Classification:
313485, 600476, 607 91
Abstract:
A method of photodynamically diagnosing or treating a contoured surface includes topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface with substantially uniform intensity visible light from a plurality of light sources generally conforming to the contoured surface. The plurality of light sources may comprise fluorescent tubes.
Scott Lundahl - Lexington MA, US Rebecca Kozodoy - Randolph MA, US Ronald Carroll - Hingham MA, US Elton Leppelmeier - Highland Height OH, US
Assignee:
Dusa Pharmaceuticals, Inc. - Wilmington MA
International Classification:
H01J 61/44 A61B 5/00
US Classification:
313485, 600476, 607 91
Abstract:
An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity.
Scott Lundahl - Lexington MA, US Rebecca Kozodoy - Randolph MA, US Ronald Carroll - Hingham MA, US Elton Leppelmeier - Highland Height OH, US
Assignee:
Dusa Pharmaceuticals, Inc. - Wilmington MA
International Classification:
A61N 5/06 A61B 6/00
US Classification:
607 88, 607 91, 600476
Abstract:
An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity.
Compositions And Methods For Reducing Photosensitivity Associated With Photodynamic Therapy
Scott Lundahl - Lexington MA, US Stuart Marcus - Mount Kisco NY, US
Assignee:
Dusa Pharmaceuticals, Inc. - Wilmington MA
International Classification:
A61K 8/00 A61Q 17/04
US Classification:
424 60, 424 93, 424 9362, 424 96, 424 59
Abstract:
The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity.
Use Of Photodynamic Therapy To Enhance Treatment With Immuno-Modulating Agents
Michael Gold - Nashville TN, US Mitchel Goldman - La Jolla CA, US Scott Lundahl - Lexington MA, US Paul Sowyrda - Medfield MA, US
International Classification:
A61K031/198
US Classification:
514561000, 604020000
Abstract:
Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy (PDT). PDT can be administered before, during or after administration of the immuno-modulating agent. Combination therapy achieves at least the same efficacy as immuno-modulatory therapy in less time, with less immuno-modulating agent and fewer side-effects.