Scott M Murphy

US Patent:

48289760, May 9, 1989

Filed:

Sep 9, 1986

Appl. No.:

6/905277

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102
A61K 3514

US Classification:

435 2

Abstract:

Novel methods and storage media for storing platelets in a viable condition for at least five days are disclosed. The disclosed methods comprise the steps of providing a platelet rich suspension of platelets and blood plasma; extracting supernatant plasma from that suspension to leave between about 1 to 15 mls of plasma per unit of blood platelets with those platelets to produce a concentrated platelet button; adding 40 to 70 ml/unit of a glucose free aqueous solution to said concentrated platelet button; agitating the resultant solution to resuspend the platelets to provide a synthetic suspension of those platelets; and storing that synthetic suspension in an oxygen permeable container at about 22. degree. C. , until needed for use. Two preferred glucose free aqueous platelet storage media are disclosed which generally comprise sodium citrate, sodium chloride, potassium chloride, and either sodium phosphate or calcium chloride, but not both.

US Patent:

52348083, Aug 10, 1993

Filed:

Oct 30, 1991

Appl. No.:

7/784695

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102

US Classification:

435 2

Abstract:

The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding acetate to a platelet concentrate.

US Patent:

54748917, Dec 12, 1995

Filed:

Jun 16, 1994

Appl. No.:

8/262045

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102

US Classification:

435 2

Abstract:

The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding storage extension additives, which include acetate, pyruvate, acetoacetate,. beta. -hydroxybutyrate, acetone,. alpha. -ketoglutarate, succinate, fumarate, malate, oxaloacetate, C. sub. 3-8 fatty acid anions, triose phosphates and mixtures thereof, to a platelet concentrate.

US Patent:

55695795, Oct 29, 1996

Filed:

Mar 17, 1994

Appl. No.:

8/210033

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102

US Classification:

435 2

Abstract:

Synthetic-based platelet storage media are provided along with methods of using the media for the storage of platelets for an extended period of time. The synthetic-based media contain phosphate and a substrate for oxidative phosphorylation and for providing buffering in the media upon oxidation selected from the group including pyruvate, butyrate, C. sub. 3-8 fatty acid anions, acetate, acetoacetate, acetone, and beta-hydroxybutyrate.

US Patent:

49923633, Feb 12, 1991

Filed:

Dec 15, 1988

Appl. No.:

7/284987

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102
A61K 3514

US Classification:

435 2

Abstract:

Novel methods and storage media for storing platelets in a viable condition for at least five days are disclosed. The disclosed methods comprise the steps of providing a platelet rich suspension of platelets and blood plasma; extracting supernatant plasma from that suspension to leave between about 1 to 15 mls of plasma per unit of blood platelets with those platelets to produce a concentrated platelet button; adding 40 to 70 ml/unit of a glucose free aqueous solution to said concentrated platelet button; agitating the resultant solution to resuspend the platelets to provide a synthetic suspension of those platelets; and storing that synthetic suspension in an oxygen permeable container at about 22. degree. C. until needed for use. Two preferred glucose free aqueous platelet storage media are disclosed which generally comprise sodium citrate, sodium chloride, potassium chloride, and either sodium phosphate or calcium chloride, but not both.

US Patent:

54665736, Nov 14, 1995

Filed:

Aug 5, 1994

Appl. No.:

8/286627

Inventors:

Scott Murphy - Ardmore PA
Tetsuo Shimizu - Kasugai, JP

Assignee:

Thomas Jefferson University - Philadephia PA

International Classification:

A01N 102

US Classification:

435 2

Abstract:

The invention is an improved platelet storage method and composition. Medium for the storage of platelets for transfusion comprising acetate or an acetate-like compound and phosphate is disclosed.

US Patent:

49256653, May 15, 1990

Filed:

Jun 22, 1989

Appl. No.:

7/369842

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3514

US Classification:

424532

Abstract:

The present invention provides a novel primary citrate anticoagulant which is essentially free of glucose and its use to optimize the viability of stored platelets. The present invention allows platelets to be stored in plasma or synthetic media without the addition of buffer. Specifically the anticoagulant consists essentially of sodium citrate and citric acid.

US Patent:

53447522, Sep 6, 1994

Filed:

Apr 7, 1993

Appl. No.:

8/043574

Inventors:

Scott Murphy - Ardmore PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 102

US Classification:

435 2

Abstract:

The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding storage extension additives to a platelet concentrate.