Scott M Norton

US Patent:

6569437, May 27, 2003

Filed:

Jul 16, 1999

Appl. No.:

09/354687

Inventors:

Michael Bishop - Dallas TX
Glen Gillis - Denton TX
Scott J. Norton - Argyle TX

Assignee:

Active Organics - Lewisville TX

International Classification:

A61K 600

US Classification:

424401, 424400, 424 941, 424 946, 424 9466

Abstract:

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically 5 acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes that exhibit proteolytic activity at pH values below that of the surface of the skin, i. e. , approximately pH 5. 5. The acidic buffer comprises inorganic and/or organic acids or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5. 5 and is susceptible to neutralization by normal epidermal processes.

US Patent:

6656701, Dec 2, 2003

Filed:

Jan 29, 2002

Appl. No.:

10/059790

Inventors:

Michael Bishop - Dallas TX
Glen Gillis - Denton TX
Scott J. Norton - Argyle TX

Assignee:

Actim Organics, Inc - Lewisville TX

International Classification:

C12Q 137

US Classification:

435 23, 435 24, 435 4, 424401

Abstract:

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i. e. , approximately pH 5. 5. The acidic buffer comprises at least one acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of the surface of the skin, i. e. , approximately pH 5. 5. or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient.

US Patent:

59765569, Nov 2, 1999

Filed:

Jun 13, 1996

Appl. No.:

8/664056

Inventors:

Scott J. Norton - Argyle TX
Michael A. Bishop - Dallas TX
Glen S. Gillis - Darmouth, CA

Assignee:

Active Organics, Inc. - Lewisville TX

International Classification:

A61K 748

US Classification:

424401

Abstract:

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i. e. , approximately pH 5. 5. The acidic buffer comprises inorganic and/or organic acids or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5. 5 and is susceptible to neutralization by normal epidermal processes.