Scott D Pegan from Riverside, CA, age 46

Kir Channel Modulators
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US Patent:

20090148861, Jun 11, 2009
Filed:

Jun 17, 2008
Appl. No.:

12/141026
Inventors:

Scott D. Pegan - Oak Park IL, US
Paul A. Slesinger - San Diego CA, US
Senyon Choe - Solana CA, US
Prafulla Aryal - San Diego CA, US
Assignee:

THE SALK INSTITUTE - San Diego CA
International Classification:

G01N 33/566
US Classification:

435 71, 436501
Abstract:

Provided is a three-dimensional structure of an alcohol bound to an alcohol-binding site of an inwardly rectifying potassium (Kir) channel, Kir channel alcohol modulators and methods for identifying Kir channel modulators.

Crimean-Congo Hemorrhagic Fever Virus Vaccine
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US Patent:

20140050761, Feb 20, 2014
Filed:

Mar 14, 2013
Appl. No.:

13/829105
Inventors:

Scott Dusan Pegan - Denver CO, US
Stuart T. Nichol - Atlanta GA, US
Michelle Kay Deaton - Denver CO, US
International Classification:

A61K 39/12
US Classification:

4242051, 4352351, 435236, 435238, 435366
Abstract:

The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent.