Scott S Turner

US Patent:

20050255509, Nov 17, 2005

Filed:

Mar 30, 2005

Appl. No.:

11/095029

Inventors:

Marc Hellerstein - Kensington CA, US
Scott Turner - Oakland CA, US

Assignee:

KineMed, Inc. - Emeryville CA

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The methods of the present invention allow for the measurement of ribonucleotide reductase (RR) activity, an important enzyme in the de novo DNA synthesis pathway. Ribonucleotide reductase converts all four ribonucleotides to their deoxy form and is a rate-controlling step in this pathway. Biosynthetic pathways of deoxyribonucleotides (dN) have received considerable attention in the context of anti-proliferative chemotherapy. Inhibitors of various steps in dN biosynthesis, including inhibitors of RR are among the most useful chemotherapeutic agents in cancer, viral infections, and other therapeutic uses. DNA synthesis from the dN salvage pathway is also an important component to DNA replication. The relative contributions from RR vs. salvage pathways are critical to the actions and effectiveness of chemotherapeutic agents that act on nucleoside metabolic pathways. Until now, however, it has not been possible to study these metabolic processes in vivo. Disclosed within are methods of measuring RR activity in vivo and in vitro which find use, among other things, in drug discovery, development, and approval.

US Patent:

20110288114, Nov 24, 2011

Filed:

Jun 22, 2009

Appl. No.:

13/001281

Inventors:

Scott Turner - Oakland CA, US
Mary Wolff - Montana CA, US

Assignee:

Kinemed, Inc. - Emeryville CA

International Classification:

A61K 31/4355
A61P 25/00
A61P 29/00

US Classification:

514291

Abstract:

A method of treating a fibrotic disease or condition in a patient comprising administering noscapine and a pharmaceutical carrier to said patient.

US Patent:

20130141040, Jun 6, 2013

Filed:

Dec 1, 2011

Appl. No.:

13/308984

Inventors:

John DeBoer - Denver CO, US
Brian Timothy McCoy - Lawrenceville GA, US
Drew Stephen Hancock - Sugar Hill GA, US
Harry Price Haas - Atlanta GA, US
Scott Clayton Turner - Lilburn GA, US

Assignee:

SIEMENS INDUSTRY, INC. - Alpharetta GA

International Classification:

H02J 7/00

US Classification:

320109, 320162

Abstract:

An electric vehicle charging system is disclosed. More particularly, the system encompasses a load center having one or more electrical loads coupled thereto, electric vehicle supply equipment (EVSE) to charge an electric vehicle (EV), and a monitoring and limiting device (MLD) to monitor power or current usage of at least the one or more loads coupled to the load center, and adjust a charging level setting of the EVSE based upon the level of the usage. MLD apparatus and methods of charging a vehicle with electric vehicle supply equipment (EVSE) are provided, as are other aspects.

US Patent:

61761737, Jan 23, 2001

Filed:

Apr 14, 1999

Appl. No.:

9/290883

Inventors:

Richard M. Holbrook - Pasadena CA
Jeff Busta - La Crescenta CA
Scott Turner - Valencia CA
Filiberto Betancourt - North Hills CA
Karel Slovacek - Irvine CA
Jeff Lam - El Monte CA
James Layfield - Fountain Valley CA

Assignee:

Thermador Corporation - Los Angeles CA

International Classification:

A47J 3704

US Classification:

99401

Abstract:

Cooking appliances, cooking assemblies, and cooking assembly components that improve heat distribution are provided. In one embodiment, a cooking assembly has a sear grid including a radiant panel having an undulating shape. The panel defines at least one generally parabolic dome with a radiused peak to allow liquids at the peak to be rapidly heated by the burner. The dome has sides extending away from the peak with a generally increasing slope to cause liquids flowing down the sides of the dome to accelerate. In another embodiment, a double U-shaped burner is provided. A U-shaped burner has a base for positioning at the front of the cooking assembly and a pair of legs that extend toward the rear of the cooking assembly. A second U-shaped connecting tube is positioned to connect the U-shaped burner base to the front of the cooking assembly housing.

US Patent:

63148714, Nov 13, 2001

Filed:

Oct 19, 2000

Appl. No.:

9/691903

Inventors:

Richard M. Holbrook - Pasadena CA
Jeff Busta - La Crescenta CA
Scott Turner - Valencia CA
Filiberto Betancourt - North Hills CA
Karel Slovacek - Irvine CA
Jeff Lam - El Monte CA
James Layfield - Fountain Valley CA

Assignee:

Thermador Corporation - Los Angeles CA

International Classification:

A47J 3704

US Classification:

99401

Abstract:

Cooking appliances, cooking assemblies, and cooking assembly components that improve heat distribution are provided. In one embodiment, a cooking assembly has a sear grid including a radiant panel having an undulating shape. The panel defines at least one generally parabolic dome with a radiused peak to allow liquids at the peak to be rapidly heated by the burner. The dome has sides extending away from the peak with a generally increasing slope to cause liquids flowing down the sides of the dome to accelerate. In another embodiment, a double U-shaped burner is provided. A U-shaped burner has a base for positioning at the front of the cooking assembly and a pair of legs that extend toward the rear of the cooking assembly. A second U-shaped connecting tube is positioned to connect the U-shaped burner base to the front of the cooking assembly housing.

US Patent:

20210147526, May 20, 2021

Filed:

Nov 13, 2020

Appl. No.:

17/098199

Inventors:

- South San Francisco CA, US
Chun Chen - Albany CA, US
Scott Turner - Oakland CA, US

International Classification:

C07K 16/18
A61K 45/06
A61P 25/28

Abstract:

Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

US Patent:

20190219585, Jul 18, 2019

Filed:

Jan 17, 2019

Appl. No.:

16/250721

Inventors:

- Rahway NJ, US
Jennifer H. Yearley - Palo Alto CA, US
Scott P. Turner - San Francisco CA, US
Belma Dogdas - Secaucus NJ, US
Ansuman Bagchi - Plainsboro NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

G01N 33/574
G16H 20/17
G16H 20/40
G06T 7/00
C07K 16/28
C12Q 1/6886
G06T 7/11
G06T 7/41
G06T 7/90
G16B 40/20

Abstract:

The present disclosure describes an IHC assay for detecting and quantifying spatially proximal pairs of PD-1-expressing cells (PD-1+ cells) and PD-Ligand-expressing cells (PD-L+ cells) in tumor tissue, and the use of the assay to generate proximity biomarkers that are predictive of which cancer patients are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods for testing tumor samples for the proximity biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.

US Patent:

20180093917, Apr 5, 2018

Filed:

Oct 3, 2016

Appl. No.:

15/283673

Inventors:

- Waltham MA, US
Sunder S. Rajan - Anaheim CA, US
Scott T. Turner - Redondo Beach CA, US
Isaac C. Chen - Alhambra CA, US

International Classification:

C03C 8/14
B28B 3/00

Abstract:

A molding composite includes mica flakes and a eutectic glaze. The composite allows making of lead-free parts for use in a variety of situations, such as electrical insulators for supporting electrically-conductive parts, such as electrodes, for electrical devices. The molded composite material can be used mold around such electrically-conductive parts, supporting them and/or providing hermetic seals around the parts. Other possible uses include substrates for electronic circuits, and housings for parts, such as electro-optical parts. The molding composite is heated under elevated pressure to liquefy the eutectic glaze, causing it to coat the mica flakes. After the composite is put into a desired shape it is solidify, for example by compressing the molding composite at a constant temperature until the eutectic glaze solidifies, followed by cooling of the molding composite.