Sean Beausoleil from 71 Herrick Rd, Newton, MA 02459, Phone: (617)9641294

Phosphopeptide Compositions And Anti-Phosphopeptide Antibody Compositions And Methods Of Detecting Phosphorylated Peptides
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US Patent:

20080214782, Sep 4, 2008
Filed:

Oct 30, 2007
Appl. No.:

11/980279
Inventors:

Steven P. Gygi - Foxborough MA, US
Judit Villen - Boston MA, US
Sean Beausoleil - Merrimack NH, US
International Classification:

C07K 7/08
C07K 5/10
C07K 7/06
C07K 16/18
C40B 40/10
C07K 19/00
C07K 2/00
C07F 9/572
US Classification:

530326, 530330, 530329, 548413, 530327, 530300, 5303891, 5303873, 506 18, 702 19
Abstract:

The present invention relates to phosphopeptide compositions and anti-phosphopeptide antibody compositions. Also provided are methods of identifying phosphorylation sites in phosphorylated peptides and phosphorylation site motifs.

Methods And Reagents For Creating Monoclonal Antibodies
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US Patent:

20120308555, Dec 6, 2012
Filed:

Mar 9, 2012
Appl. No.:

13/416582
Inventors:

Roberto Polakiewicz - Lexington MA, US
Wan Cheung Cheung - Lexington MA, US
Sean Andre Beausoleil - Essex MA, US
Assignee:

CELL SIGNALING TECHNOLOGY, INC. - Danvers MA
International Classification:

C40B 20/08
A61K 39/395
C07K 16/00
US Classification:

4241301, 506 6, 5303871
Abstract:

In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a polyclonal population of antibodies such as a non-specific polyclonal population or a polyclonal population of antibodies that specifically bind to the antigen. The method includes obtaining nucleic acid molecules encoding heavy and light immunoglobulin chains (or variable regions thereof) of multiple immunoglobulins from an animal; obtaining mass spectra information of peptide fragments of a population of polyclonal immunoglobulins that specifically bind to an antigen of choice; comparing and/or correlating the mass spectra information of the peptide fragments of the polyclonal immunoglobulins with predicted mass spectra information of predicted amino acid sequences encoded by the nucleic acid molecules, and then assembling the heavy and light chains to create an antibody (or variable region thereof) that specifically binds to the antigen.

Anti-Il1Rap Antibodies And Antibody Drug Conjugates
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US Patent:

20220267455, Aug 25, 2022
Filed:

Dec 22, 2021
Appl. No.:

17/559301
Inventors:

- Beverly MA, US
Scott Michael Lonning - Westford MA, US
Jason G. Beaudet - Beverly MA, US
Sean A. Beausoleil - Essex MA, US
Nels Eric Pederson - Mansfield MA, US
Daniel Mulhern - Somerville MA, US
International Classification:

C07K 16/28
A61K 47/68
A61P 35/00
Abstract:

Disclosed herein are Interleukin 1 Receptor Accessory Protein (IL1RAP) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Anti-Ly6H Antibodies And Antibody Drug Conjugates
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US Patent:

20200308298, Oct 1, 2020
Filed:

Jun 28, 2018
Appl. No.:

16/624612
Inventors:

- Beverly MA, US
Scott Michael Lonning - Westford MA, US
Nels Eric Pederson - Mansfield MA, US
Aleksandr Tkachev - Cambridge MA, US
Klarisa Rikova - Reading MA, US
Sean A. Beausoleil - Essex MA, US
International Classification:

C07K 16/30
C07K 16/28
A61P 35/00
Abstract:

Disclosed herein are anti-lymphocyte antigen 6 complex, locus H (LY6H) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Anti-Il1Rap Antibodies And Antibody Drug Conjugates
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US Patent:

20200140561, May 7, 2020
Filed:

Jun 12, 2018
Appl. No.:

16/620386
Inventors:

- Beverly MA, US
Scott Michael Lonning - Westford MA, US
Jason G. Beaudet - Beverly MA, US
Sean A. Beausoleil - Essex MA, US
Nels Eric Pederson - Mansfield MA, US
Daniel Mulhern - Somerville MA, US
International Classification:

C07K 16/28
A61K 47/68
A61P 35/00
Abstract:

Disclosed herein are Interleukin 1 Receptor Accessory Protein (IL1RAP) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Methods And Reagents For Creating Monoclonal Antibodies
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US Patent:

20190002532, Jan 3, 2019
Filed:

Jan 19, 2018
Appl. No.:

15/875615
Inventors:

- Danvers MA, US
Wan Cheung Cheung - Lexington MA, US
Sean Andre Beausoleil - Essex MA, US
Assignee:

Cell Signaling Technology, Inc. - Danvers MA
International Classification:

C07K 16/00
C07K 16/18
C07K 16/08
C07K 16/44
Abstract:

In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a polyclonal population of antibodies such as a non-specific polyclonal population or a polyclonal population of antibodies that specifically bind to the antigen. The method includes obtaining nucleic acid molecules encoding heavy and light immunoglobulin chains (or variable regions thereof) of multiple immunoglobulins from an animal; obtaining mass spectra information of peptide fragments of a population of polyclonal immunoglobulins that specifically bind to an antigen of choice; comparing and/or correlating the mass spectra information of the peptide fragments of the polyclonal immunoglobulins with predicted mass spectra information of predicted amino acid sequences encoded by the nucleic acid molecules, and then assembling the heavy and light chains to create an antibody (or variable region thereof) that specifically binds to the antigen.

Anti-Human Cytomegalovirus Antibodies And Use Thereof
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US Patent:

20150110794, Apr 23, 2015
Filed:

Apr 30, 2013
Appl. No.:

14/398074
Inventors:

- Danvers MA, US
Sean Andre Beausoleil - Essex MA, US
Wan Cheung Cheung - Lexington MA, US
Roberto D. Polakiewicz - Lexington MA, US
International Classification:

C07K 16/08
G01N 33/569
US Classification:

4241391, 5303879, 536 2353, 4353201, 4352523, 435 5, 435238, 43525233, 43525235, 43525411, 4352542, 435331
Abstract:

This disclosure provides anti-human cytomegalovirus antibodies and methods of treatment, prophylaxis, detection, and diagnosis using the same. In another aspect, the disclosure features therapeutic, prophylactic, and/or diagnostic compositions for human cytomegalovirus infection or for a human cytomegalovirus-related disease that include a binding agent (e.g., antibody) or polynucleotide disclosed herein. In some embodiments, the composition is formulated for ocular or topical administration. The compositions can further include one or more human cytomegalovirus-neutralizing antibodies, an intravenous immunoglobulin preparation, and/or one or more antiviral compounds (e.g., ganciclovir, foscamet, cidofovir, or valganciclovir).