Sean T Gallagher

US Patent:

6518024, Feb 11, 2003

Filed:

Dec 13, 1999

Appl. No.:

09/459685

Inventors:

Vi-En Choong - Chandler AZ
Song Shi - Phoenix AZ
George Maracas - Phoenix AZ
Sean Gallagher - Scottsdale AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 2433

Abstract:

This invention relates to apparatus and methods for detecting single base extension to an oligonucleotide array using electrochemical labels.

US Patent:

6572830, Jun 3, 2003

Filed:

Jun 21, 1999

Appl. No.:

09/337086

Inventors:

Jeremy W. Burdon - Scottsdale AZ
Rong-Fong Huang - Tempe AZ
David Wilcox - Albuquerque NM
Nicholas J. Naclerio - Barrington IL
Cynthia Ann Gorsuch Briscoe - Tempe AZ
Piotr Grodzinski - Chandler AZ
Huinan Yu - Chandler AZ
Robert Marrero - Chandler AZ
Sean Ross Gallagher - Scottsdale AZ
Barbara McNeil Foley - Phoenix AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

B01J 1000

US Classification:

42218629, 422129, 422186, 422240, 156 8911, 156 8912, 219678, 219687, 219756

Abstract:

A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure.

US Patent:

6605454, Aug 12, 2003

Filed:

Mar 22, 2001

Appl. No.:

09/816512

Inventors:

Barbara Foley Barenburg - Gilbert AZ
Jeremy Burdon - Scottsdale AZ
Sean Gallagher - Scottsdale AZ
Piotr Grodzinski - Chandler AZ
Robert Marrero - Chandler AZ
Vijay Nair - Mesa AZ
David Rhine - Phoenix AZ
Thomas Smekal - Phoenix AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

C12N 1300

US Classification:

4351737, 219690, 219691, 219692, 219693, 422 22

Abstract:

A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The microwave radiation from the MMIC is useful for heating samples introduced into the microfluidic structure and for effecting lysis of cells in the samples. Microfabrication techniques allow the fabrication of MMICs that perform heating and cell lysing of samples having volumes in the microliter to picoliter range.

US Patent:

20030096283, May 22, 2003

Filed:

Sep 27, 2002

Appl. No.:

10/259532

Inventors:

Vi-En Choong - Chandler AZ, US
Song Shi - Phoenix AZ, US
George Maracas - Phoenix AZ, US
Sean Gallagher - Scottsdale AZ, US

Assignee:

Motorola Inc, A Corporation of the State of Delaware

International Classification:

C12Q001/68
C12M001/34

US Classification:

435/006000, 435/287200, 205/777500

Abstract:

This invention relates to apparatus and methods for detecting single base extension to an oligonucleotide array using electrochemical labels.

US Patent:

20030209432, Nov 13, 2003

Filed:

Feb 28, 2003

Appl. No.:

10/149319

Inventors:

Vi-En Choong - Chandler AZ, US
Sean Gallagher - Claremont CA, US
Mike Gaskin - Chandler AZ, US
Changming Li - Phoeniz AZ, US
George Maracas - Phoenix AZ, US
Song Shi - Phoenix AZ, US

International Classification:

G01N027/26

US Classification:

204/403130, 204/403140

Abstract:

This invention relates to the detection of molecular interactions between biological molecules. Specifically, the invention relates to electrical detection of interactions such as hybridization between nucleic acids or peptide antigen-antibody interaction using arrays of peptides or oligonucleotides. In particular, the invention relates to an apparatus and methods for detecting nucleic acid hybridization or peptide binding using electronic methods including AC impedance. In some embodiments, no electrochemical or other label moieties are used. In others, electrochemically active labels are used to detect reactions on hydrogel arrays, including genotyping reactions such as the single base extension reaction.

US Patent:

62039857, Mar 20, 2001

Filed:

Sep 8, 1998

Appl. No.:

9/149506

Inventors:

Wenbin Jiang - Phoenix AZ
Barbara M. Foley - Phoenix AZ
Sean Gallagher - Scottsdale AZ
Davis H. Hartman - Chandler AZ
Huinan Yu - Phoenix AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

A bio-molecule analyzer includes an array of addressable light sources, a photoconductive layer of material having a layer of electrically conductive material on a surface thereof mounted on the array of addressable light sources, and a plurality of test sites on an opposing surface of the photoconductive layer of material defined by the plurality of light sources. A solution containing a plurality of bio-molecules is positioned in electrical contact with the plurality of test sites. An electrical potential is connected between the solution and the layer of electrically conductive material, whereby the array of addressable light sources emit beams of light through a plurality of portions of the photoconductive layer of material to define the test sites and complete electrical circuits between the layer of electrically conductive material and the solution.

US Patent:

59367300, Aug 10, 1999

Filed:

Sep 8, 1998

Appl. No.:

9/149507

Inventors:

Barbara M. Foley - Phoenix AZ
Wenbin Jiang - Phoenix AZ
Davis H. Hartman - Chandler AZ
Huinan Yu - Phoenix AZ
Sean Gallagher - Scottsdale AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

G01N 2100
G01N 2101
G01N 2702
G01B 902

US Classification:

356344

Abstract:

A bio-molecule analyzer including a plurality of test sites on a transparent substrate, each test site having probe molecules attached thereto. An array of addressable light sources are positioned in optical alignment with a corresponding test site. A solution containing sample molecules is positioned in contact with the plurality of test sites. A detector array having a plurality of photodetectors positioned in optical alignment with the array of addressable light sources, one photodetector corresponding to each light source, and a light filter positioned between the detector array and the plurality of test sites for absorbing the light from the light sources and transmitting the light from the test sites to the detector array.