Seble H Wagaw

US Patent:

6465693, Oct 15, 2002

Filed:

Jan 18, 2001

Appl. No.:

09/765072

Inventors:

Stephen L. Buchwald - Newton MA
Seble Wagaw - Cambridge MA
O. Geis - Berlin, DE

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07C20900

US Classification:

564386, 564250, 564251, 564389, 564391, 564405, 564407

Abstract:

A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

US Patent:

8193346, Jun 5, 2012

Filed:

Dec 4, 2008

Appl. No.:

12/328380

Inventors:

Seble Wagaw - Evanston IL, US
Matthew Ravn - Round Lake IL, US
Kenneth Engstrom - Mundelein IL, US
Guoyou Xu - Framingham MA, US
Zhe Wang - Hockessin DE, US
Ying Sun - Waltham MA, US
Deqiang Niu - Lexington MA, US
Yat Sun Or - Watertown MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

C07K 5/08
C07K 5/12

US Classification:

540460, 540471

Abstract:

The present invention relates to a process for the preparation of macrocyclic compounds that are useful as hepatitis C virus (HCV) protease inhibitor compounds.

US Patent:

20080058528, Mar 6, 2008

Filed:

Jul 19, 2007

Appl. No.:

11/779936

Inventors:

Todd McDermott - Libertyville IL, US
Seble Wagaw - Evanston IL, US
Kenneth Engstrom - Mundelein IL, US
Jorge Gandarilla - North Riverside IL, US
Albert Kruger - Pleasant Prairie WI, US
Michael Rozema - Kenosha WI, US
Michael Fickes - Evanston IL, US
Steven Wittenberger - Mundelein IL, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Thomas Borchardt - Kenosha WI, US

International Classification:

C07D 221/00
C07D 207/04
C07F 7/02
C07D 213/02

US Classification:

546193000, 546327000, 548400000, 548406000, 548532000, 548537000, 548540000, 548566000

Abstract:

A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.

US Patent:

20100144608, Jun 10, 2010

Filed:

Sep 10, 2009

Appl. No.:

12/584716

Inventors:

Yiyin Ku - Buffalo Grove IL, US
Keith F. McDaniel - Wauconda IL, US
Hui-Ju Chen - Grayslake IL, US
Jason P. Shanley - Chicago IL, US
Dale J. Kempf - Libertyville IL, US
David J. Grampovnik - Waukegan IL, US
Ying Sun - Waltham MA, US
Dong Liu - Newton MA, US
Yonghua Gai - North Grafton MA, US
Yat Sun Or - Watertown MA, US
Seble H. Wagaw - Evanston IL, US
Ken Engstrom - Mundelein IL, US
Tim Grieme - Chicago IL, US
Ahmad Sheikh - Deerfield IL, US
Jianzhang Mei - Lake Forest IL, US

International Classification:

A61K 38/12
C07D 487/04
A61P 31/12

US Classification:

514 11, 540460

Abstract:

The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

US Patent:

20100317568, Dec 16, 2010

Filed:

Jun 10, 2010

Appl. No.:

12/813301

Inventors:

David A. DeGoey - Salem WI, US
Warren M. Kati - Gurnee IL, US
Charles W. Hutchins - Green Oaks IL, US
Pamela L. Donner - Mundelein IL, US
Allan C. Krueger - Gurnee IL, US
John T. Randolph - Libertyville IL, US
Christopher E. Motter - Oak Creek WI, US
Lissa T. Nelson - Highland Park IL, US
Sachin V. Patel - Round Lake IL, US
Mark A. Matulenko - Libertyville IL, US
Ryan G. Keddy - Beach Park IL, US
Tammie K. Jinkerson - Pleasant Prairie WI, US
Todd N. Soltwedel - Chicago IL, US
Dachun Liu - Waukegan IL, US
John K. Pratt - Kenosha WI, US
Todd W. Rockway - Grayslake IL, US
Clarence J. Maring - Palatine IL, US
Douglas K. Hutchinson - Antioch IL, US
Charles A. Flentge - Salem WI, US
Rolf Wagner - Antioch IL, US
Michael D. Tufano - Chicago IL, US
David A. Betebenner - Libertyville IL, US
Michael J. Lavin - Des Plaines IL, US
Kathy Sarris - Mundelein IL, US
Kevin R. Woller - Antioch IL, US
Seble H. Wagaw - Evanston IL, US
Jean C. Califano - Whitefish Bay WI, US
Wenke Li - Gurnee IL, US
Daniel D. Caspi - Evanston IL, US
Mary E. Bellizzi - North Chicago IL, US

Assignee:

ABBOTT LABAORATORIES - Abbott Park IL

International Classification:

A61K 38/05
C07D 403/14
A61P 31/14
C07D 401/14
A61K 31/4178
A61K 31/4184
C07D 413/14
C07D 417/14
A61K 31/428
A61K 31/496
A61K 31/5377
A61K 31/55
C07F 9/6506
A61K 31/675
C07D 491/113
A61K 31/438
C07D 279/12
A61K 31/541

US Classification:

514 42, 548518, 546187, 5483131, 514397, 5483054, 514394, 544141, 544131, 548159, 5462791, 514367, 544370, 51425406, 5142345, 540603, 51421709, 548112, 514 94, 546 19, 514278, 544 585, 5142278

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

US Patent:

20110092415, Apr 21, 2011

Filed:

Oct 13, 2010

Appl. No.:

12/903822

Inventors:

David A. DeGoey - Salem WI, US
Warren M. Kati - Gurnee IL, US
Charles W. Hutchins - Green Oaks IL, US
Pamela L. Donner - Mundelein IL, US
Allan C. Krueger - Gurnee IL, US
John T. Randolph - Libertyville IL, US
Christopher E. Motter - Oak Creek WI, US
Lissa T. Nelson - Highland Park IL, US
Sachin V. Patel - Round Lake IL, US
Mark A. Matulenko - Libertyville IL, US
Ryan G. Keddy - Beach Park IL, US
Tammie K. Jinkerson - Pleasant Prairie WI, US
Todd N. Soltwedel - Chicago IL, US
Dachun Liu - Vernon Hills IL, US
John K. Pratt - Kenosha WI, US
Todd W. Rockway - Grayslake IL, US
Clarence J. Maring - Palatine IL, US
Douglas K. Hutchinson - Antioch IL, US
Charles A. Flentge - Salem WI, US
Rolf Wagner - Antioch IL, US
Michael D. Tufano - Chicago IL, US
David A. Betebenner - Libertyville IL, US
Michael J. Lavin - Des Plaines IL, US
Kathy Sarris - Mundelein IL, US
Kevin R. Woller - Antioch IL, US
Seble H. Wagaw - Evanston IL, US
Jean C. Califano - Whitefish Bay WI, US
Wenke Li - Gurnee IL, US
Daniel D. Caspi - Evanston IL, US
Mary E. Bellizzi - North Chicago IL, US
William A. Carroll - Evanston IL, US

Assignee:

ABBOTT LABAORATORIES - Abbott Park IL

International Classification:

A61K 38/05
C07D 403/14
C07D 401/14
C07D 405/14
C07D 413/14
C07D 491/113
A61P 31/14

US Classification:

514 43, 5483054, 546199, 5462734, 548236, 546112, 546 16, 546 19, 5483131

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

US Patent:

20110207699, Aug 25, 2011

Filed:

Dec 9, 2010

Appl. No.:

12/964027

Inventors:

David A. DeGoey - Salem WI, US
Warren M. Kati - Gurnee IL, US
Charles W. Hutchins - Green Oaks IL, US
Pamela L. Donner - Mundelein IL, US
Allan C. Krueger - Gurnee IL, US
John T. Randolph - Libertyville IL, US
Christopher E. Motter - Oak Creek WI, US
Lissa T. Nelson - Highland Park IL, US
Sachin V. Patel - Round Lake IL, US
Mark A. Matulenko - Libertyville IL, US
Ryan G. Keddy - Beach Park IL, US
Tammie K. Jinkerson - Pleasant Prairie WI, US
Todd N. Soltwedel - Chicago IL, US
Douglas K. Hutchinson - Antioch IL, US
Charles A. Flentge - Salem WI, US
Rolf Wagner - Antioch IL, US
Clarence J. Maring - Palatine IL, US
Michael D. Tufano - Chicago IL, US
David A. Betebenner - Grayslake IL, US
Todd W. Rockway - Grayslake IL, US
Dachun Liu - Vernon Hills IL, US
John K. Pratt - Kenosha WI, US
Michael J. Lavin - Des Plaines IL, US
Kathy Sarris - Mundelein IL, US
Kevin R. Woller - Antioch IL, US
Seble H. Wagaw - Evanston IL, US
Jean C. Califano - Whitefish Bay WI, US
Wenke Li - Gurnee IL, US
Daniel D. Caspi - Evanston IL, US
Mary E. Bellizzi - North Chicago IL, US
William A. Carroll - Evanston IL, US

Assignee:

ABBOTT LABAORATORIES - Abbott Park IL

International Classification:

A61K 31/695
C07D 401/14
A61K 31/454
C07F 5/02
A61K 31/69
C07D 401/10
C07D 403/14
A61K 31/4178
A61K 31/496
A61K 31/506
C07D 413/14
A61K 31/5377
A61K 31/397
C07F 7/10
A61P 31/18

US Classification:

514 63, 546199, 514322, 546210, 514326, 546 13, 514 64, 5483131, 514397, 544370, 51425406, 546 16, 514278, 546 19, 544295, 51425219, 544139, 5142345, 51421021, 546 14

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

US Patent:

20120004196, Jan 5, 2012

Filed:

May 4, 2011

Appl. No.:

13/100827

Inventors:

David A. DeGoey - Salem WI, US
Warren M. Kati - Gurnee IL, US
Charles W. Hutchins - Green Oaks IL, US
Pamela L. Donner - Mundelein IL, US
Allan C. Krueger - Gurnee IL, US
John T. Randolph - Libertyville IL, US
Christopher E. Motter - Oak Creek WI, US
Lissa T. Nelson - Highland Park IL, US
Sachin V. Patel - Round Lake IL, US
Mark A. Matulenko - Libertyville IL, US
Ryan G. Keddy - Beach Park IL, US
Tammie K. Jinkerson - Pleasant Prairie WI, US
Yi Gao - Vernon Hills IL, US
Dachun Liu - Vernon Hills IL, US
John K. Pratt - Kenosha WI, US
Todd W. Rockway - Grayslake IL, US
Clarence J. Maring - Palatine IL, US
Douglas K. Hutchinson - Antioch IL, US
Charles A. Flentge - Salem WI, US
Rolf Wagner - Antioch IL, US
Michael D. Tufano - Chicago IL, US
David A. Betebenner - Grayslake IL, US
Kathy Sarris - Mundelein IL, US
Kevin R. Woller - Antioch IL, US
Seble H. Wagaw - Evanston IL, US
Jean C. Califano - Whitefish Bay WI, US
Wenke Li - Gurnee IL, US
Daniel D. Caspi - Evanston IL, US
Mary E. Bellizzi - Lake Forest IL, US
William A. Carroll - Evanston IL, US

Assignee:

ABBOTT LABAORATORIES - Abbott Park IL

International Classification:

A61K 31/4184
C07D 401/14
C07D 405/14
C07D 413/14
C07F 7/10
A61K 31/454
A61K 31/4439
A61K 31/422
A61K 31/438
A61K 31/4545
A61K 31/695
A61K 31/496
A61K 31/506
A61K 31/5377
A61P 31/14
C07D 403/14

US Classification:

514 63, 5483054, 546199, 5462734, 548236, 546 16, 546194, 546 14, 544370, 544331, 544139, 514394, 514322, 514338, 514374, 514278, 514318, 51425406, 514275, 5142345

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.