Seok Man Hong

US Patent:

20190307693, Oct 10, 2019

Filed:

Apr 9, 2018

Appl. No.:

15/949000

Inventors:

- San Antonio TX, US
- Evanston IL, US
Robert D. GALIANO - Glenview IL, US
Seok Jong HONG - Northbrook IL, US
Ping XIE - Chicago IL, US
Shengxian JIA - Wilmette IL, US

International Classification:

A61K 9/127
A61K 31/366
A61K 9/00
A61K 47/26

Abstract:

A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.

US Patent:

20190225684, Jul 25, 2019

Filed:

Jan 22, 2019

Appl. No.:

16/253735

Inventors:

- Evanston IL, US
Seok Jong Hong - Northbrook IL, US
Robert D. Galiano - Chicago IL, US
Thomas A. Mustoe - Evanston IL, US

International Classification:

C07K 16/28
A61K 31/496
A61K 38/08
A61K 31/4965
A61K 31/519
A61K 31/7088
A61K 31/4375
A61K 31/7064
A61K 31/4709
A61K 31/498
A61K 31/5377
A61K 31/52
A61K 31/685
A61K 31/366
A61K 31/352
A61K 31/415
A61K 31/26
A61K 31/12
C12N 15/113
A61K 31/421
A61K 31/5415
A61K 31/405
A61K 31/407
A61K 31/42
A61K 31/635

Abstract:

The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or an inhibitor of the Na/SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating skin conditions (e.g., dermatitis, psoriasis, or other skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a gene or protein selected from: ENac, COX-2, PGE2, PI3K, PKB, NaPrss8, IL-1β, IL-8, SAPK, Erk gene, p38 gene, PAR2, S100A8, S100A9, S100A12.

US Patent:

20170044255, Feb 16, 2017

Filed:

Aug 19, 2016

Appl. No.:

15/241841

Inventors:

- Evanston IL, US
Seok Jong Hong - Northbrook IL, US
Robert D. Galiano - Chicago IL, US
Thomas A. Mustoe - Evanston IL, US

International Classification:

C07K 16/28
C12N 15/113

Abstract:

The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or an inhibitor of the Na/SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating skin conditions (e.g., dermatitis, psoriasis, or other skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a gene or protein selected from: ENac, COX-2, PGE2, PI3K, PKB, NaPrss8, IL-1β, IL-8, SAPK, Erk gene, p38 gene, PAR2, S100A8, S100A9, S100A12.

US Patent:

20150065431, Mar 5, 2015

Filed:

Aug 27, 2014

Appl. No.:

14/469823

Inventors:

- Evanston IL, US
Seok Jong Hong - Northbrook IL, US
Robert D. Galiano - Chicago IL, US
Thomas A. Mustoe - Evanston IL, US

International Classification:

A61K 38/07
A61K 31/519
C12N 15/113
A61K 31/635
A61K 31/42
A61K 31/407
A61K 31/405
A61K 31/5415
A61K 31/421
A61K 31/12
A61K 31/26
A61K 31/496
A61K 31/415
A61K 31/352
A61K 31/366
A61K 31/685
A61K 31/52
A61K 31/5377
A61K 31/498
A61K 31/4709
A61K 31/7064
A61K 31/4375
A61K 9/00
A61K 31/7088
A61K 31/4965

US Classification:

514 186, 51425506, 514249, 514 44 A, 514158, 514378, 514411, 514420, 5142265, 514374, 514679, 514514, 51425411, 514406, 514455, 514453, 514 77, 51426321, 5142322, 514314, 514 27, 5142651, 514293

Abstract:

The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or an inhibitor of the Na/SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating skin conditions (e.g., dermatitis, psoriasis, or other skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a gene or protein selected from: ENac, COX-2, PGE2, PI3K, PKB, NaPrss8, IL-1β, IL-8, SAPK, Erk gene, p38 gene, PAR2, S100A8, S100A9, S100A12.