Seongmin Lee

US Patent:

20040087820, May 6, 2004

Filed:

Aug 7, 2003

Appl. No.:

10/636129

Inventors:

Philip Fuchs - West Lafayette IN, US
Seongmin Lee - West Lafayette IN, US

International Classification:

C07C027/00

US Classification:

568/959000

Abstract:

The invention provides a catalytic, chemospecific and stereospecific method of oxidizing a wide variety of substrates without unwanted side reactions. Essentially, the method of the instant invention, under relatively mild reaction conditions, catalytically, stereospecifically and chemospecifically inserts oxygen into a hydrocarbon C—H bond. Oxidation (oxygen insertion) at a tertiary C—H bond to form an alcohol (and in some cases a hemiacetal) at the tertiary carbon is favored. The stereochemistry of an oxidized tertiary carbon is preserved. Ketones are formed by oxidizing a secondary C—H bond and ring-cleaved diones are formed by oxidizing cis tertiary CH bonds.