Sergey V Ryzhov from Cape Elizabeth, ME, age 52

Use Of Adenosine Receptor Ligands To Promote Cell Adhesion In Cell-Based Therapies
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US Patent:

20090136460, May 28, 2009
Filed:

Jul 10, 2008
Appl. No.:

12/170883
Inventors:

Italo Biaggioni - Nashville TN, US
Igor Feoktistov - Nashville TN, US
Antonis K. Hatzopoulos - Nashville TN, US
Sergey Ryzhov - Nashville TN, US
Douglas E. Vaughan - Chicago IL, US
International Classification:

A61K 35/12
US Classification:

424 937
Abstract:

Intracoronary delivery of endothelial progenitor cells (EPCs) is an emerging concept for the treatment of cardiovascular disease, and enhancement of EPC adhesion to vascular endothelium should improve cell retention within targeted organs, as well as vascular development. The present inventors have shown that stimulation of adenosine receptors (AdoR) in murine embryonic EPCs (eEPCs) and cardiac endothelial cells (cECs) rapidly, within minutes, increased eEPC adhesion to cECs. eEPCs and cECs were found to predominantly express functional Aand AAdoR subtypes, respectively, and both subtypes are involved in the regulation of eEPC adhesion to cECs. Adenosine, adenosine precursors (e.g., AMP) and adenosine receptor agonists thus can be used to stimulate EPC/stem cell homing and engraftment in cell-based therapies.