Heidi A. Tissenbaum - Wayland MA, US Seung Wook Oh - Lewisville TX, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
C12Q 1/48 G01N 33/53
US Classification:
435 15, 435 71
Abstract:
The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended lifespan is associated with DAF-16 phosphorylation by JNK-1 and the consequent DAF-16 localization to the nucleus. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having a JNK signaling pathway and, optionally, an IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity, to prevent or reduce obesity and to prevent or treat type II diabetes.
Alcoholic Beverage Control Liquor Licensing Bankruptcy Bank Foreclosures Commercial Loans Consumer Loans Loan Restructuring Secured Lending Business Law Civil Practice Commercial Real Estate Contracts Corporate Law Leases and Leasing Personal Injury Drivers License Suspension DUI/DWI
ISLN:
920067473
Admitted:
1995
University:
University of Virginia, B.A., 1991
Law School:
Suffolk University School of Law, J.D., 1995
Name / Title
Company / Classification
Phones & Addresses
Seung Woo Oh Director, President
GLOBAL MANNAPOWER, INC
1330 Mac Arthur Dr #2, Carrollton, TX 75007 11536 Harry Hines Blvd, Dallas, TX 75229 1315 Riverchase Dr, Coppell, TX 75019
Adam Daniels, Steven Petrovas, Andrew Belcastro, Charles Norris, Jose Lanzagorta, Phillip Poole, Chris Brown, Rajiv Rhyne, Marut Shah, Aaron Hulseman, Dennis Austin