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ISLN:
920067473
Admitted:
1995
University:
University of Virginia, B.A., 1991
Law School:
Suffolk University School of Law, J.D., 1995
Us Patents
Methods Of Identifying Longevity Modulators And Therapeutic Methods Of Use Thereof
Heidi A. Tissenbaum - Wayland MA, US Seung Wook Oh - Lewisville TX, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
C12Q 1/48 G01N 33/53
US Classification:
435 15, 435 71
Abstract:
The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended lifespan is associated with DAF-16 phosphorylation by JNK-1 and the consequent DAF-16 localization to the nucleus. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having a JNK signaling pathway and, optionally, an IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity, to prevent or reduce obesity and to prevent or treat type II diabetes.
Youtube
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Tennistavolo Tischtennis Bordtennis Top sin Topspin Tenis de mesa Tenn...
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12 Apr, 2011
Duration:
6m 15s
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Category:
Entertainment
Uploaded:
01 Mar, 2011
Duration:
3m 32s
My princess MV Lee Seol and Park Hae Young- Y...
This is a fanvideo about My Princess drama! I hope you'll like it! Sce...
Category:
Entertainment
Uploaded:
28 Feb, 2011
Duration:
3m 44s
Korean Open 2011: Lin Gaoyuan-Oh Sang Eun
Watch the full match at ittf.com This video is the property of Total S...
Category:
Sports
Uploaded:
02 Jul, 2011
Duration:
6m 8s
Japan Open 2011: Ryu Seung Min-Taku Takakiwa
Watch the full match at ittf.com This video is the property of Total S...
Category:
Sports
Uploaded:
08 Jul, 2011
Duration:
6m 31s
WTTC 2007: Ryu Seung Min - OH Sang Eun parte 1
WTTC 2007 round 16 ryu seung min vs oh sang eun 4-3
Category:
Sports
Uploaded:
14 Jul, 2011
Duration:
10m 45s
Googleplus
Seung Oh
Relationship:
Its_complicated
About:
To be continued...
Tagline:
Korean-American, currently in recovery
Bragging Rights:
High School Diploma (Class of 2007) , fluent in both English & Korean (speak, read, & write)...I had bragging rights "once upon a time"
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