Shannon Sue Marshall

US Patent:

20160130348, May 12, 2016

Filed:

Oct 29, 2015

Appl. No.:

14/926732

Inventors:

- Gaithersburg MD, US
Linda Liu - Clarksville MD, US
Shannon Marshall - Baltimore MD, US
Sheng Yao - Columbia MD, US

International Classification:

C07K 16/28

Abstract:

The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.

US Patent:

20160039905, Feb 11, 2016

Filed:

Apr 6, 2015

Appl. No.:

14/679497

Inventors:

- Gaithersburg MD, US
Linda Liu - Clarksville MD, US
Joseph R. Podojil - Downers Grove IL, US
Stephen D. Miller - Oak Park IL, US
Shannon Marshall - Baltimore MD, US

International Classification:

C07K 14/705

Abstract:

Fusion proteins containing B7-II4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by Th1, Th1 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.