Sharon A Jenkins

US Patent:

58914447, Apr 6, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/474446

Inventors:

Sharon Jenkins - Peabody MA
Yichen Lu - Wellesley MA
Lendon Payne - Arlington MA
Bryan Roberts - Cambridge MA

Assignee:

Virus Research Institute, Inc. - Cambridge MA

International Classification:

A61K 3921
A61K 5100
A61K 3942
A61K 39385

US Classification:

4242081

Abstract:

A composition and method for inducing a protective immune response to HIV-1 in an individual, of (a) a replication incompetent HIV-1, HIV-1 pseudovirus, HIV-1 VLP or oligomeric gp120; and (b) a water soluble polyphosphazene polyelectrolyte, wherein (a) and (b) are present in an amount effective to induce a protective immune response against HIV-1.

US Patent:

55297773, Jun 25, 1996

Filed:

Nov 4, 1993

Appl. No.:

8/147781

Inventors:

Alexander K. Andrianov - Belmont MA
Sharon A. Jenkins - Peabody MA
Lendon G. Payne - Arlington MA
Bryan E. Roberts - Cambridge MA

Assignee:

Virus Research Institute - Cambridge MA

International Classification:

A61K 3900
A61K 3938
A61K 950
A61K 914

US Classification:

4241841

Abstract:

Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stable microparticle. Preferred polymers are alginate and polyphosphazenes, and mixtures thereof. Microparticles can be adminstered parenterally or mucosally. For oral delivery, the microparticles are preferably fifteen microns or less in diameter, and adhere to the mucosal lining of the gastrointestinal tract, increasing uptake by the reticuloendothelium.

US Patent:

54946735, Feb 27, 1996

Filed:

Jul 11, 1994

Appl. No.:

8/273285

Inventors:

Alexander K. Andrianov - Belmont MA
Sharon A. Jenkins - Peabody MA
Lendon G. Payne - Arlington MA
Bryan E. Roberts - Cambridge MA

Assignee:

Virus Research Institute - Cambridge MA

International Classification:

A61K 3939
A61K 3929
A61K 3902
A61K 29145

US Classification:

4242801

Abstract:

An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.

US Patent:

62071718, Mar 27, 2001

Filed:

Mar 25, 1999

Appl. No.:

9/276024

Inventors:

Lendon G. Payne - Arlington MA
Angela L. Woods - West Roxbury MA
Sharon A. Jenkins - Bethlehem NH

Assignee:

Avant Immunotherapeutics, Inc. - Needham MA

International Classification:

A61K39/39

US Classification:

4242801

Abstract:

A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere and which is adsorbed with antigen after formation of the microsphere. The immunoadjuvant can be administered intranasally.

US Patent:

62615734, Jul 17, 2001

Filed:

Oct 25, 1999

Appl. No.:

9/426361

Inventors:

Jean R. Loebelenz - Essex MA
Bryan E. Roberts - Cambridge MA
Sharon A. Jenkins - Bethlehem NH

Assignee:

Avant Immunotherapeutics, Inc. - Needham MA

International Classification:

A61K 4500
A61K 5100

US Classification:

4242781

Abstract:

The present invention provides immunogenic compositions and methods for inducing enhanced immune responses using an antigen and a combination of water soluble polymer and an amphiphilic compound.