Sharon Lynn Myers

US Patent:

20050014679, Jan 20, 2005

Filed:

Dec 12, 2002

Appl. No.:

10/496847

Inventors:

John Beals - Indianapolis IN, US
Michael DeFelippis - Carmel IN, US
Richard DiMarchi - Carmel IN, US
Wayne Kohn - Indianapolis IN, US
Radmila Micanovic - Indianapolis IN, US
Sharon Myers - Indianapolis IN, US
Kingman Ng - Carmel IN, US
Lianshan Zhang - Carmel IN, US

International Classification:

A61K038/28

US Classification:

514003000, 530303000

Abstract:

The present invention provides an insulin molecule that provides a protracted, even basal duration of action. The insulin molecule comprises a modification at the N-terminus of the A-chain, optionally a modification at the N-terminus of the B-chain, a modification at a B-chain lysine, and optionally a modification at the C-terminus of the A-chain. The present invention also provides a method of treating diabetes mellitus comprising administering the insulin molecule.

US Patent:

20050176621, Aug 11, 2005

Filed:

Jun 20, 2003

Appl. No.:

10/600031

Inventors:

Mark Brader - Indianapolis IN, US
Sharon Myers - Indianapolis IN, US
Muppalla Sukumar - Indianapolis IN, US

International Classification:

A61K038/00

US Classification:

514002000

Abstract:

The present invention relates to insulin crystals formed from zinc, protamine, a hexamer-stabilizing compound, and a polypeptide selected from the group consisting of insulin, an insulin analog, and a derivatized insulin. The crystals are suitable for administering to a patient for control of blood glucose levels. The crystals have been derived from the neutral protamine Hagedorn (NPH) form in a process utilizing precisely determined protamine concentrations and fortification of NPH crystals formed at a first lower concentration of protamine to achieve a second higher concentration of protamine.