Sharon Elizabeth Potter

US Patent:

55590349, Sep 24, 1996

Filed:

Jun 1, 1995

Appl. No.:

8/457552

Inventors:

Walden K. Roberts - Denver CO
Claude P. Selitrennikoff - Evergreen CO
Bridget E. Laue - Davis CA
Sharon L. Potter - Raleigh NC

Assignee:

Ciba-Geigy Corporation - Tarrytown NY

International Classification:

C12N 1500
C12N 120
C07H 1900
C07H 2100

US Classification:

4353201

Abstract:

Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.

US Patent:

59818441, Nov 9, 1999

Filed:

Dec 19, 1997

Appl. No.:

8/994418

Inventors:

Walden K. Roberts - Denver CO
Claude P. Selitrennikoff - Evergreen CO
Bridget E. Laue - Davis CA
Sharon L. Potter - Raleigh NC

Assignee:

Novartis Finance Corporation - New York NY
University Research Corporation - Boulder CO

International Classification:

A01H 500
A01H 510

US Classification:

800301

Abstract:

Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.

US Patent:

55211534, May 28, 1996

Filed:

Jan 10, 1994

Appl. No.:

8/178708

Inventors:

Walden K. Roberts - Denver CO
Claude P. Selitrennikoff - Evergreen CO
Bridget E. Laue - Davis CA
Sharon L. Potter - Raleigh NC

Assignee:

Ciba-Geigy Corporation - Tarrytown NY

International Classification:

A01N 3718
A61K 3800
C07K 100
C07K 1400

US Classification:

514 2

Abstract:

Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.

US Patent:

57030448, Dec 30, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/456430

Inventors:

Walden K. Roberts - Denver CO
Claude P. Selitrennikoff - Evergreen CO
Bridget E. Laue - Davis CA
Sharon L. Potter - Raleigh NC

Assignee:

Novartis Finance Corporation - New York NY

International Classification:

A61K 3816
C07K 14415

US Classification:

514 12

Abstract:

Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.