Shawn Anthony Barrett

US Patent:

20190272894, Sep 5, 2019

Filed:

Mar 1, 2019

Appl. No.:

16/290713

Inventors:

- Cambridge MA, US
Jagdish C. Tewari - Bridgewater NJ, US
Xuezhen Kang - Bridgewater NJ, US
Marina Hincapie - Bridgewater NJ, US
Shawn L. Barrett - Bridgewater NJ, US
Julie Susanne Pollock - Bridgewater NJ, US
Lin Huang - Bridgewater NJ, US

International Classification:

G16C 20/10
C12M 1/00
C12M 1/36
C12M 1/12
C07K 1/16

Abstract:

The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.