Shawn A Scranton

US Patent:

20070027184, Feb 1, 2007

Filed:

Jul 27, 2006

Appl. No.:

11/496784

Inventors:

James Malecha - San Diego CA, US
Stewart Noble - San Diego CA, US
Brandon Wiley - Philadelphia PA, US
Timothy Hoffman - San Diego CA, US
Celine Bonnefous - San Diego CA, US
Michael Sertic - Euclid OH, US
Paul Wash - San Diego CA, US
Nicholas Smith - San Diego CA, US
Christian Hassig - Mira Mesa CA, US
Shawn Scranton - San Diego CA, US
Joseph Payne - Oceanside CA, US
Jeffery Hager - San Diego CA, US

International Classification:

A61K 31/47
C07D 215/12
C07D 319/14
A61K 31/36

US Classification:

514311000, 514465000, 514452000, 546176000, 549362000, 549454000

Abstract:

Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

US Patent:

20070135431, Jun 14, 2007

Filed:

Dec 8, 2006

Appl. No.:

11/608726

Inventors:

Nicholas Smith - San Diego CA, US
Celine Bonnefous - San Diego CA, US
Joseph Payne - San Diego CA, US
Timothy Hoffman - San Diego CA, US
Paul Wash - San Diego CA, US
Christian Hassig - San Diego CA, US
Shawn Scranton - San Diego CA, US

Assignee:

KALYPSYS, INC - San Diego CA

International Classification:

A61K 31/5377
A61K 31/454
A61K 31/4439
C07D 413/14
C07D 401/14

US Classification:

514235200, 514326000, 514340000, 544124000, 546207000, 546277100

Abstract:

Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

US Patent:

20070135438, Jun 14, 2007

Filed:

Dec 8, 2006

Appl. No.:

11/608736

Inventors:

Joseph Payne - San Diego CA, US
Nicholas Smith - San Diego CA, US
Shawn Scranton - San Diego CA, US
Christian Hassig - San Diego CA, US

Assignee:

KALYPSYS, INC. - San Diego CA

International Classification:

A61K 31/53
A61K 31/4965
C07D 253/08
A61K 31/505

US Classification:

514242000, 514255060, 514275000, 544183000, 544330000, 544406000

Abstract:

Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

US Patent:

20060252807, Nov 9, 2006

Filed:

Apr 20, 2006

Appl. No.:

11/409451

Inventors:

Daniel Severance - San Diego CA, US
Elisabeth Gardiner - San Diego CA, US
Stewart Noble - San Diego CA, US
Boliang Lou - Louisville KY, US
Allen Borchardt - San Diego CA, US
Jeffrey Roppe - Temecula CA, US
Mehmet Kahraman - San Diego CA, US
Dana Siegel - San Diego CA, US
Shawn Scranton - San Diego CA, US

International Classification:

C07D 417/04
A61K 31/433
A61K 31/426

US Classification:

514362000, 548137000, 514365000, 548190000

Abstract:

The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.