UCLA Pathology Outreach 10833 Le Conte Ave BLDG CHS, Los Angeles, CA 90095 (310)2672680 (phone), (310)2672685 (fax)
Education:
Medical School Med Coll, Calicut Univ, Calicut, Kerala, India Graduated: 1994
Languages:
English
Description:
Dr. Pullarkat graduated from the Med Coll, Calicut Univ, Calicut, Kerala, India in 1994. She works in Los Angeles, CA and specializes in Clinical Pathology. Dr. Pullarkat is affiliated with Harbor UCLA Medical Center.
University of California at Los Angeles
10833 Le Conte Ave, Los Angeles, CA 90095 Ronald Reagan Ucla Medical Center
757 Westwood Plz, Los Angeles, CA 90095
Education:
Calicut University Medical College - Kerala (1994)
Heinz-Josef Lenz - Altadena CA, US Sheeja Thankappan Pullarkat - Glendale CA, US Yi Ping Xiong - Alhambra CA, US
International Classification:
C12Q 1/68 G01N 27/447
US Classification:
435 612, 435 613, 204450
Abstract:
The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism with the effectiveness of the drugs or regimens, or by associating genomic polymorphism with the intratumoral expression of a gene whereby the gene expression affects effectiveness of the drugs or regimens. In particular, the present invention provides novel methods for screening therapeutic regimens, which comprise determining a patient's genotype at a tandemly repeated 28 base pair region in the thymidilate synthase (TS) gene's 5′ untranslated region (UTR). Patients homozygous for a triple repeat will be least successfully treated with a thymidylate synthase directed drug, while those heterozygous for a triple and a double repeat will be more successfully treated, and those homozygous for a double repeat will be even more successfully treated. Those patients homozygous for the double repeat will likely suffer the least side effects from thymidylate synthase directed drugs such as 5-FU.
Genomic Polymorphism For Predicting Therapeutic Response
Heinz-Josef Lenz - Altadena CA, US Sheeja Thankappan Pullarkat - Glendale CA, US Yi Ping Xiong - Alhambra CA, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism with the effectiveness of the drugs or regimens, or by associating genomic polymorphism with the intratumoral expression of a gene whereby the gene expression affects effectiveness of the drugs or regimens. In particular, the present invention provides novel methods for screening therapeutic regimens, which comprise determining a patient's genotype at a tandemly repeated 28 base pair region in the thymidilate synthase (TS) gene's 5′ untranslated region (UTR). Patients homozygous for a triple repeat will be least successfully treated with a thymidylate synthase directed drug, while those heterozygous for a triple and a double repeat will be more successfully treated, and those homozygous for a double repeat will be even more successfully treated. Those patients homozygous for the double repeat will likely suffer the least side effects from thymidylate synthase directed drugs such as 5-FU.
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