Sheung Lee Kam

US Patent:

47988924, Jan 17, 1989

Filed:

Apr 14, 1986

Appl. No.:

6/851629

Inventors:

Sheung T. Kam - Chicago IL
William L. Matier - Libertyville IL
Ghanshyam Patil - Vernon Hills IL

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07D30754
C07D33338

US Classification:

544146

Abstract:

The present invention relates to compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR. sub. 2 COR. sub. 1, --NR. sub. 2 CONR. sub. 1 R. sub. 3, --NR. sub. 2 SO. sub. 2 R. sub. 1, NR. sub. 2 SO. sub. 2 NR. sub. 1 R. sub. 3, or --NR. sub. 2 COOR. sub. 1, wherein R. sub. 1, R. sub. 2 and R. sub. 3 may be alike or different and may be hydrogen, alkyl, alkoxyalkyl cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R. sub. 1 is not hydrogen when B is --NR. sub. 2 SO. sub. 2 R. sub. 1 or --NR. sub. 2 COOR. sub. 1, or R. sub. 1 and R. sub. 3 may together with N form a 5 to 7 membered heterocyclic group and the pharmaceutically acceptable salts thereof. The compounds exhibit beta-adrenergic blocking activity and are also useful in the treatment of glaucoma.

US Patent:

45828555, Apr 15, 1986

Filed:

Nov 12, 1981

Appl. No.:

6/320773

Inventors:

Sheung T. Kam - Vernon Hills IL
William L. Matier - Libertyville IL

Assignee:

American Hospital Supply Corporation - Evanston IL

International Classification:

C07C 6976
C07C12506
C07D33332
C07D33336

US Classification:

514487

Abstract:

Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR. sub. 2 COR. sub. 1, --NR. sub. 2 CONR. sub. 1 R. sub. 3, --NR. sub. 2 SO. sub. 2 R. sub. 1, --NR. sub. 2 SO. sub. 2 NR. sub. 1 R. sub. 3, or --NR. sub. 2 COOR. sub. 1 wherein R. sub. 1, R. sub. 2 and R. sub. 3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R. sub. 1 is not hydrogen when B is --NR. sub. 2 SO. sub. 2 R. sub. 1 or --NR. sub. 2 COOR. sub. 1, or R. sub. 1 and R. sub. 3 may together with N form a 5 to 7 momoered heterocyclic group; and the pharmaceutically acceptable salts thereof. These compounds exhibit. beta.

US Patent:

49354213, Jun 19, 1990

Filed:

Mar 1, 1989

Appl. No.:

7/318147

Inventors:

Sheung T. Kam - Vernon Hills IL
William L. Matier - Libertyville IL

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

A61K 31535
C07D24516
C07D24518

US Classification:

5142375

Abstract:

Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR. sub. 2 COR. sub. 1, --NR. sub. 2 CONR. sub. 1 R. sub. 3, --NR. sub. 2 SO. sub. 2 R. sub. 1, --NR. sub. 2 SO. sub. 2 NR. sub. 1 R. sub. 3, or --NR. sub. 2 COOR. sub. 1 wherein R. sub. 1, R. sub. 2 and R. sub. 3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R. sub. 1 is not hydrogen when B is --NR. sub. 2 SO. sub. 2 R. sub. 1 or --NR. sub. 2 COOR. sub. 1, or R. sub. 1 and R. sub. 3 may together with N form a 5 to 7 membered heterocyclic group; and the pharmaceutically acceptable salts thereof. These compounds exhibit. beta.

US Patent:

48107174, Mar 7, 1989

Filed:

Mar 10, 1986

Appl. No.:

6/838082

Inventors:

Sheung T. Kam - Vernon Hills IL
William L. Matier - Libertyville IL

Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE

International Classification:

C07D23366
C07D26348
C07D20944
C07D33502

US Classification:

514377

Abstract:

Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR. sub. 2 COR. sub. 1, --NR. sub. 2 CONR. sub. 1 R. sub. 3, --NR. sub. 2 SO. sub. 2 R. sub. 1, --NR. sub. 2 SO. sub. 2 NR. sub. 1 R. sub. 3, or --NR. sub. 2 COOR. sub. 1 wherein R. sub. 1, R. sub. 2 and R. sub. 3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R. sub. 1 is not hydrogen when B is --NR. sub. 2 SO. sub. 2 R. sub. 1 or --NR. sub. 2 COOR. sub. 1, or R. sub. 1 and R. sub. 3 may together with N form a 5 to 7 membered heterocyclic group; and the pharmaceutically acceptable salts thereof. These compounds exhibit. beta.