Shing Fai Kwan

US Patent:

61435376, Nov 7, 2000

Filed:

Jan 5, 1999

Appl. No.:

9/225905

Inventors:

Shing F. Kwan - Lake Forest CA
Ivan E. Modrovich - Camarillo CA
Rebecca J. Hunt - Carpinteria CA

Assignee:

Medical Analysis Systems, Inc. - Camarillo CA

International Classification:

G01N 3353
G01N 33573
C12Q 137
C12Q 132
C12Q 996

US Classification:

435188

Abstract:

A method for stabilizing analyses with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and then cooling and filtering the solution. The filtered solution may be diluted in a suitable matrix.

US Patent:

56609787, Aug 26, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/483375

Inventors:

Shing Fai Kwan - Ventura CA
Ivan E. Modrovich - Camarillo CA
Rebecca Jolene Hunt - Carpinteria CA

International Classification:

C12Q 170

US Classification:

435 5

Abstract:

A method for stabilizing analytes with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and then cooling and filtering the solution. The filtered solution may be diluted in a suitable matrix.

US Patent:

57534535, May 19, 1998

Filed:

Mar 6, 1995

Appl. No.:

8/398908

Inventors:

Shing Fai Kwan - Ventura CA

International Classification:

C12Q 132
C12Q 148
G01N 3350

US Classification:

435 15

Abstract:

A stable single reagent for the determination of carbon dioxide in serum is provided as an aqueous solution of diagnostically amounts and NADH and/or NADPH, and a stabilizing system therefore reactively stabilized PEPC and a substrate for reacting with bicarbonate ion under alkaline conditions in the presence of PEPC.

US Patent:

55567886, Sep 17, 1996

Filed:

May 9, 1994

Appl. No.:

8/239610

Inventors:

Shing F. Kwan - Ventura CA

Assignee:

Medical Analysis Systems, Inc. - Camarillo CA

International Classification:

G01N 3374

US Classification:

436 87

Abstract:

A system for determining the concentration of fructosamine in sera which consists of a first reagent in which a tetrazolium salt which reduces all reactive substances in sera including fructosamine and a second reagent which is responsive to all reactive substance in sera other than fructosamine. The difference in color change as between the two allows the determination of concentration of fructosamine.

US Patent:

59104228, Jun 8, 1999

Filed:

May 10, 1991

Appl. No.:

7/700996

Inventors:

Ivan E. Modrovich - Camarillo CA
Shing S. Kwan - Camarillo CA
Leon C. Wortham - Canoga Park CA

Assignee:

Medical Analysis Systems, Inc. - Camarillo CA

International Classification:

C12Q 140

US Classification:

435 22

Abstract:

A stable, single liquid alpha-amylase assay reagent comprises a polysaccharide or long chain oligosaccharide substrate for alpha-amylase having an optically detectable label bonded to the reducing end glucose, by a bond cleavable by alpha- or beta-glucosidase, and a blocking group bonded to the terminal end glucose. The reagent further comprises beta-amylase and either alpha- or beta-glucosidase. Sorbitol is provided in an amount of about 5% to retard degradation of the enzymes. Zwitterionic buffers are also provided to stabilize the enzymes. In preparing the reagent, the enzymes and substrate are filtered through a 0. 2 micron or less filter to remove alpha-amylase producing organisms.

US Patent:

52485986, Sep 28, 1993

Filed:

May 25, 1989

Appl. No.:

7/357025

Inventors:

Shing F. Kwan - Ventura CA
Rebecca J. Hunt - Carpinteria CA

International Classification:

C12Q 134

US Classification:

435 18

Abstract:

A single system reagent for the determination of lipase, formulated as an emulsion comprising a lipase-active fatty acid source; a first lipase activator comprising colipase; a second lipase activator; a lipoprotein lipase inhibitor; a first emulsion stabilizer comprising Triton X100; a second emulsion stabilizer; a buffer; and an anti-precipitant.

US Patent:

53127609, May 17, 1994

Filed:

Jun 8, 1992

Appl. No.:

7/895606

Inventors:

Shing F. Kwan - Ventura CA

Assignee:

Modrovich, Ivan Endre - Camarillo CA

International Classification:

G01N 3374

US Classification:

436 87

Abstract:

A system for determining the concentration of fructosamine in sera which consists of a first reagent in which a tetrazolium salt which reduces all reactive substances in sera including fructosamine and a second reagent which is responsive to all reactive substance in sera other than fructosamine. The difference in color change as between the two allows the determination of concentration of fructosamine.

US Patent:

53786092, Jan 3, 1995

Filed:

Apr 29, 1991

Appl. No.:

7/693856

Inventors:

Shing F. Kwan - Ventura CA
Rebecca J. Hunt - Carpinteria CA

International Classification:

C12Q 134

US Classification:

435 18

Abstract:

A single system reagent for the determination of lipase, formulated as an emulsion comprising a lipase-active fatty acid source; a first lipase activator comprising colipase; a second lipase activator; a lipoprotein lipase inhibitor; an emulsion stabilizer comprising Triton X100; a buffer; and an antiprecipitant.