Shu Hui Liu

US Patent:

57928355, Aug 11, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/477082

Inventors:

Daphne C. Tse - Duarte CA
Samia S. Mankarious - Costa Mesa CA
Shu Len Liu - Cerritos CA
William R. Thomas - Laguna Nigel CA
Melaine Alpern - Long Beach CA
Stanley T. Enomoto - Van Nuys CA
Cataline M. Garanchon - Northridge CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K 3836

US Classification:

530382

Abstract:

A method for preparing a fibrinogen-containing composition derived from human plasma by separating a cryoprecipitate from the plasma, suspending the cryoprecipitate in a salt-containing buffer, treating the supernatant by affinity-chromatography on a lysine-bound solid matrix to allow plasminogen to adsorb thereon, collecting a fraction containing less than 10. mu. g/ml plasminogen, and treating the fraction to reduce viral activity. The fibrinogen-containing composition recovered from this fraction is advantageous because it contains such a low amount of plasminogen that no addition of fibrinolysis inhibitor is needed.

US Patent:

57166455, Feb 10, 1998

Filed:

Apr 16, 1996

Appl. No.:

8/632922

Inventors:

Daphne C. Tse - Duarte CA
Samia S. Mankarious - Costa Mesa CA
Shu Len Liu - Cerritos CA
William R. Thomas - Laguna Nigel CA
Melaine Alpern - Long Beach CA
Stanley T. Enomoto - Van Nuys CA
Cataline M. Garanchon - Northridge CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K 3516

US Classification:

424530

Abstract:

A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as being free of detectable levels of lipid enveloped virus activity, free of prothrombin complex and active thrombin, and contains no protease inhibitors or other non-human proteins. Also, described is a method for producing the composition.