Shu Takeda

US Patent:

20060165683, Jul 27, 2006

Filed:

Oct 31, 2002

Appl. No.:

10/497326

Inventors:

Gerard Karsenty - Houston TX, US
Shu Takeda - Houston TX, US
Florent Elefteriou - Houston TX, US

International Classification:

A61K 39/395
A61K 31/60
A61K 31/517
A61K 31/4745
A61K 31/404
A61K 31/137

US Classification:

424143100, 514165000, 514651000, 514252170, 514283000, 514414000

Abstract:

This invention relates to methods for treatment, diagnosis and prevention of bone disease and comprises methods including measurement and modulation of sympathetic tone and leptin activity. Alteration of sympathetic tone in bone disease can be accomplished by decreasing or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. Alteration of sympathetic tone in bone disease can also be accomplished in the foregoing manner, in combination with traditional sympathetic nervous system agonists and/or antagonists, such as, but not limited to, a dopamine β hydroxylase antagonist or a β adrenergic antagonist for treatment or prevention of osteoporosis.