Shuwen Wang from Liberty Lake, WA, age 61

Resumes

Clinical Associate Professor, Department Of Pharmaceutical Sciences

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Location:

Spokane, WA

Industry:

Research

Work:

Washington State University at Spokane Wa
Clinical Associate Professor, Department of Pharmaceutical Sciences
Penn State University May 1, 2000 - Dec 1, 2013
Associate Professor
Elan Nov 1, 1997 - Apr 1, 2000
Researcher
Ucsf Dec 1, 1992 - Oct 1, 1997
Postdoctoral Fellow

Education:

Geisel School of Medicine at Dartmouth 1986 - 1992
Doctorates, Doctor of Philosophy, Biochemistry Peking University 1981 - 1985

Skills:

Cell
Molecular Biology
Cell Biology
Biochemistry
Immunohistochemistry
Genomics
Cancer
Genetics
Immunology
Western Blotting
Epigenetics
Protein Purification
Oncology
Molecular Cloning
Drosophila Genetics and Neural Development
Rnai
High Throughput Screening
Transgenic Mice
Telomerase Gene Regulation and Telomere Biology
Stem Cell Research
Bac Recombineering
Recombinase Mediated Bac Targeting In Mammalian Cells
Cell Differentiation
Northern and Southern Blotting
Bioluminescent Imaging In Live Animals
Bac Transgenics
Viral Immunology

Languages:

English
Mandarin

Certifications:

Internet History, Technology, and Security
Virology I: How Viruses Work

Shuwen Wang

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Shuwen Wang

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Wikipedia

Wang Shuwen

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Wang Shuwen () (d. 806), was an official of the Chinese dynasty Tang Dynasty. He was a close associate of Emperor Shunzong (Li Song) while Li Song was crown prince ...

Wang Pi

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Wang Pi () (d. 805?) was an official of the Chinese Tang Dynasty, who was a close associate of Emperor Shunzong (Li Song). He, along with his ally Wang Shuwen, was ...

Us Patents

Beta-Secretase Enzyme Compositions And Methods
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US Patent:

7276349, Oct 2, 2007
Filed:

Mar 25, 2005
Appl. No.:

11/090872
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12Q 1/37
C12N 9/64
C07K 1/00
US Classification:

435 23, 435226, 530350
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Beta-Secretase Enzyme Compositions And Methods
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US Patent:

7427478, Sep 23, 2008
Filed:

Feb 28, 2005
Appl. No.:

11/069377
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12Q 1/37
C12N 5/00
C12N 9/64
A64K 38/00
C07K 1/00
US Classification:

435 6, 435325, 435 721, 435226, 435 23, 530300, 530350, 536 232
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Β-Secretase Enzyme Compositions And Methods
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US Patent:

7456007, Nov 25, 2008
Filed:

Dec 24, 1999
Appl. No.:

09/471669
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Millbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12N 9/64
C12N 15/00
C12N 5/00
C12P 21/06
C12Q 1/68
US Classification:

435226, 4353201, 435325, 435 691, 435 6, 435 23, 4352523, 4352524, 435348, 536 232, 536412
Abstract:

Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (APP and APPsw) are also disclosed. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Β-Secretase Enzyme Compositions And Methods
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US Patent:

7262043, Aug 28, 2007
Filed:

Mar 25, 2005
Appl. No.:

11/090399
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12N 9/64
C12P 21/06
US Classification:

435226, 435 691
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Beta-Secretase Enzyme Compositions And Methods
view source
US Patent:

20050164294, Jul 28, 2005
Filed:

Mar 25, 2005
Appl. No.:

11/090866
Inventors:

John Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12Q001/68
C07H021/04
C12N009/64
US Classification:

435006000, 435069100, 435226000, 435320100, 435325000, 536023200
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw-) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Beta-Secretase Enzyme Compositions And Methods
view source
US Patent:

20050164327, Jul 28, 2005
Filed:

Mar 25, 2005
Appl. No.:

11/089918
Inventors:

John Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C12Q001/37
US Classification:

435023000
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Beta-Secretase Enzyme Compositions And Methods
view source
US Patent:

20090144840, Jun 4, 2009
Filed:

Aug 14, 2008
Appl. No.:

12/191950
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

G01N 33/573
A01K 67/027
US Classification:

800 18, 435 74
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Beta-Secretase Enzyme Compositions And Methods
view source
US Patent:

20110281752, Nov 17, 2011
Filed:

Mar 23, 2011
Appl. No.:

13/070413
Inventors:

John P. Anderson - San Francisco CA, US
Guriqbal Basi - Palo Alto CA, US
Minh Tam Doan - Hayward CA, US
Normand Frigon - Milbrae CA, US
Varghese John - San Francisco CA, US
Michael Power - Fremont CA, US
Sukanto Sinha - San Francisco CA, US
Gwen Tatsuno - Oakland CA, US
Jay Tung - Belmont CA, US
Shuwen Wang - Hershey PA, US
Lisa McConlogue - Burlingame CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

C40B 30/04
C07K 16/40
C40B 30/08
C12N 9/50
G01N 33/573
US Classification:

506 9, 435219, 435 71, 506 11, 435 792, 5303893
Abstract:

Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.