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Shyamal G Desai

age ~50

from Media, PA

Also known as:
  • Shyamal Gautam Desai
  • Shyama G Desai
  • Shayamal G Desai
  • Shyama A Desai
  • I Desai
  • L Desai
  • C Desai

Shyamal Desai Phones & Addresses

  • Media, PA
  • Fort Washington, PA
  • 734 Lucy Ct, South Plainfield, NJ 07080 • (908)5610929
  • s
  • 114 Whiteland Hills Cir, Exton, PA 19341 • (908)5610929
  • 123 Esplanade Ave, Kenner, LA 70065 • (504)4650626
  • College Station, TX
  • Houston, TX
  • New Castle, DE
  • Bratton, PA
  • Newark, DE
  • Chester, PA

Work

  • Position:
    Professional/Technical

Education

  • Degree:
    High school graduate or higher

Us Patents

  • Method Of Cancer Detection And Treatment

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  • US Patent:
    20100111874, May 6, 2010
  • Filed:
    Mar 17, 2008
  • Appl. No.:
    12/532375
  • Inventors:
    Leroy F. Liu - Bridgewater NJ, US
    Shyamal Desai - Somerset NJ, US
    Johnson Yin-Nam Lau - Newport Beach CA, US
  • Assignee:
    University of Medicine and Dentistry of New Jresey - Somerset NJ
  • International Classification:
    A61K 49/00
    A61K 31/203
    A61K 38/21
    A61K 38/19
    A61K 31/4375
    C12Q 1/68
    G01N 33/53
    G01N 33/574
    A61P 35/00
  • US Classification:
    424 92, 514559, 424 854, 424 851, 514283, 435 6, 435 721, 435 723
  • Abstract:
    The present invention provides methods for detecting and treating cancer. In some embodiments, levels of ISG15 are determined, and topoisomerase I and II inhibitors as well as other DNA-damaging agents plus agents that increase the expression of ISG15 are selected and administered.
  • Compositions And Methods For Detecting Proteinopathies

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  • US Patent:
    20210320969, Oct 14, 2021
  • Filed:
    Mar 29, 2021
  • Appl. No.:
    17/215980
  • Inventors:
    - Baton Rouge LA, US
    Shyamal D. Desai - Metairie LA, US
  • International Classification:
    H04L 29/08
  • Abstract:
    This invention is directed to compositions and methods for detecting proteinopathies.
  • Compositions And Methods For Detecting Proteinopathies

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  • US Patent:
    20180120334, May 3, 2018
  • Filed:
    Nov 17, 2017
  • Appl. No.:
    15/816998
  • Inventors:
    - BATON ROUGE LA, US
    Shyamal D. Desai - Metairie LA, US
  • International Classification:
    G01N 33/68
    A61K 31/52
    A61K 31/713
  • Abstract:
    This invention is directed to compositions and methods for detecting proteinopathies.
  • Therapeutic And Diagnostic Method For Ataxia-Telangiectasia

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  • US Patent:
    20170196871, Jul 13, 2017
  • Filed:
    Mar 21, 2017
  • Appl. No.:
    15/464473
  • Inventors:
    Shyamal D. Desai - Metairie LA, US
  • Assignee:
    Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - New Orleans LA
  • International Classification:
    A61K 31/52
    G01N 33/68
  • Abstract:
    ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T. Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients. In addition, an inhibitor of the early phase of autophagy, 3-MA, was shown to be effective in decreasing the impaired proteasome-mediated protein degradation in A-T cells, and thus would be effective in decreasing the neurodegeneration in A-T patients.
  • Therapeutic And Diagnostic Method For Ataxia-Telangiectasia

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  • US Patent:
    20160216279, Jul 28, 2016
  • Filed:
    Nov 29, 2012
  • Appl. No.:
    13/688384
  • Inventors:
    Shyamal D. Desai - Metairie LA, US
  • International Classification:
    G01N 33/68
    A61K 31/52
    A61K 31/713
  • Abstract:
    ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients. In addition, an inhibitor of the early phase of autophagy, 3-MA, was shown to be effective in decreasing the impaired proteasome-mediated protein degradation in A-T cells, and thus would be effective in decreasing the neurodegeneration in A-T patients.

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Shyamal Maheshbhai Desai

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Middleton, Milton Keynes, UK

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Work:
MBN - VP
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Youtube

Welcome To College Baljeet - Episode 3: " A W...

www.WatchBaljeet... www. Boxedlightmedia.... www.Truephresh.c... De...

  • Category:
    Comedy
  • Uploaded:
    01 Mar, 2011
  • Duration:
    7m 8s

Gujarat

"Jityu Hamesha Gujarat " is an Anthem for Gujarat sung by 25 celebrity...

  • Category:
    People & Blogs
  • Uploaded:
    11 Feb, 2009
  • Duration:
    4m 19s

Manna Dey & Lata - Mere Ae Dil Bata - Jhanak ...

"Jhanak Jhanak Payal Baaje" [1955] is an Indian Hindi film and winner ...

  • Category:
    Entertainment
  • Uploaded:
    16 Sep, 2010
  • Duration:
    4m 29s

Kishore - Dil Ko Dekho - Sachaa Jhutha [1970]

"Sachaa Jhutha" [1970] is an Indian Hindi film directed by Manmohan De...

  • Category:
    Entertainment
  • Uploaded:
    22 Nov, 2010
  • Duration:
    3m 54s

Kishore & Lata - Gum Hai Kisi Ke Pyar Mein - ...

Raampur Ka Lakshman is a 1972 Indian Hindi movie directed by Manmohan ...

  • Category:
    Entertainment
  • Uploaded:
    29 Apr, 2008
  • Duration:
    3m 59s

Children's Hindi Song - Tera Mujhse Hai Pehle...

Aa Gale Lag Jaa (English language:Come, Embrace me) is a 1973 Hindi ro...

  • Category:
    Entertainment
  • Uploaded:
    31 May, 2010
  • Duration:
    4m 16s

Kishore - Tera Mujhse Hai Pehle Ka Naata Koi ...

Aa Gale Lag Jaa (English language:Come, Embrace me) is a 1973 Hindi ro...

  • Category:
    Entertainment
  • Uploaded:
    31 May, 2010
  • Duration:
    4m 45s

Sting operations on Blue Film CD sold near Sh...

Right under the nose of the Shukrawar Peth police chowkie and a stones...

  • Category:
    News & Politics
  • Uploaded:
    20 Apr, 2009
  • Duration:
    5m 2s

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