Sigmund E Lasker

US Patent:

20060069044, Mar 30, 2006

Filed:

Sep 6, 2005

Appl. No.:

11/220078

Inventors:

Sigmund Lasker - New York NY, US
Biswajit Lahiri - Yorktown Heights NY, US

International Classification:

A61K 31/727

US Classification:

514026000, 514054000, 514056000

Abstract:

This invention provides a composition comprising a depolymerized glycosaminoglycan or derivative thereof covalently linked to a bile acid. This invention also provides a pharmaceutical composition comprising a depolymerized glycosaminoglycan or derivative thereof covalently linked to a bile acid and a pharmaceutically acceptable carrier. Finally, this invention provides a method for orally delivering heparin to a subject comprising administering to the subject a pharmaceutically effective amount of a pharmaceutical composition comprising a glycosaminoglycan or derivative thereof covalently linked to a bile acid and (b) a pharmaceutically acceptable carrier.

US Patent:

20090275543, Nov 5, 2009

Filed:

Feb 4, 2009

Appl. No.:

12/365470

Inventors:

Sigmund E. Lasker - New York NY, US
Biswajit Lahiri - Yorktown Heights NY, US

International Classification:

A61K 31/56
C07J 31/00

US Classification:

514177, 552550

Abstract:

This invention provides a composition comprising a depolymerized glycosaminoglycan or derivative thereof covalently linked to a bile acid. This invention also provides a pharmaceutical composition comprising a depolymerized glycosaminoglycan or derivative thereof covalently linked to a bile acid and a pharmaceutically acceptable carrier. Finally, this invention provides a method for orally delivering heparin to a subject comprising administering to the subject a pharmaceutically effective amount of a pharmaceutical composition comprising a glycosaminoglycan or derivative thereof covalently linked to a bile acid and (b) a pharmaceutically acceptable carrier.

US Patent:

54399033, Aug 8, 1995

Filed:

Jan 7, 1994

Appl. No.:

8/178768

Inventors:

Sigmund E. Lasker - Roosevelt Island NY

International Classification:

C07D23358
A61K 31445

US Classification:

514184

Abstract:

Stable, organometallic complexes of 5,5-diphenyl-2,4 imidazolidenedione (diphenyl hydantoin) are versatile biocides, effective when applied topically or parenterally to animal tissue, and when applied topically to plants. The diphenyl Hydantoin complexes are seen to prevent animal and plant tissue infections, and may be combined with other materials to inhibit infection.

US Patent:

53398149, Aug 23, 1994

Filed:

Apr 14, 1992

Appl. No.:

7/869547

Inventors:

Sigmund E. Lasker - New York NY

International Classification:

A61B 5055

US Classification:

1286534

Abstract:

The present invention provides a process for visualizing tissue metabolism in a subject comprising injecting. sup. 17 O. sub. 2 into the peritoneal cavity of a subject and detecting formed H. sub. 2. sup. 17 O in tissues of the subject. The. sup. 17 O. sub. 2 is injected as a gas or as microbubbles formed from an aqueous protein solution.

US Patent:

55715214, Nov 5, 1996

Filed:

Feb 13, 1995

Appl. No.:

8/387251

Inventors:

Sigmund E. Lasker - Valhalla NY

International Classification:

A61K 906
A61K 914
A61L 1500

US Classification:

424409

Abstract:

Compositions containing silver ammonium phenytoin complex and a phenytoin are usefully employed, particularly when applied topically, for the treatment of animal or human tissue, for wound healing and are useful in wound dressing preparations for the prevention or treatment of infections. The compositions are usefully applied by direct topical application to the wound or tissue to be treated or may be directly applied to the wound or tissue or incorporated in or coated on a dressing, such as a bandage.

US Patent:

52986241, Mar 29, 1994

Filed:

Nov 12, 1992

Appl. No.:

7/974686

Inventors:

Sigmund E. Lasker - New York NY

International Classification:

C07D23922
C07F 110

US Classification:

548107

Abstract:

Stable, organometallic complexes of 5,5-diphenyl-2,4 imidazolidenedione (diphenyl hydantoin) are versatile biocides, effective when applied topically or parenterally to animal tissue, and when applied topically to plants. The diphenyl Hydantoin complexes are seen to prevent animal and plant tissue infections, and may be combined with other materials to inhibit infection.

US Patent:

49960415, Feb 26, 1991

Filed:

Aug 19, 1988

Appl. No.:

7/234339

Inventors:

Toshiyuki Arai - Okazaki, Sakyo-ku, Kyoto 606, JP
Pradeep M. Gupte - Tallman, Monsey NY
Sigmund E. Lasker - New York NY

International Classification:

G01N 2400
A61B 600

US Classification:

424 9

Abstract:

A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a complex of oxygen-17, a biologically acceptable liquid carrier, such as a perfluorinated compound, and an emulsifying agent, and wherein the agent has an average particle size of less than about 0. 6 microns, and an ionic composition essentially equal to that of blood. Useful information can be obtained, and in certain instances, therapy administered, by a non-envasive imaging technique relative to tissue perfusion by. sup. 19 F-NMR (imaging of. sup. 19 F) and oxygen utilization by. sup. 1 H-NMR (imaging of H. sub. 2. sup. 17 O as a metabolite).