Simon L Yu

US Patent:

6808906, Oct 26, 2004

Filed:

May 8, 2002

Appl. No.:

10/142662

Inventors:

Mary Shen - Newark CA
Simon Yu - Newark CA
Xian Wu - Redwood City CA
Donald Payan - Hillsborough CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 1566

US Classification:

435 9141, 435 9151, 4353201, 435325, 43525233, 435489

Abstract:

The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.

US Patent:

7034145, Apr 25, 2006

Filed:

Sep 3, 2004

Appl. No.:

10/933855

Inventors:

Mary Shen - Newark CA, US
Simon Yu - Newark CA, US
Xian Wu - Redwood City CA, US
Donald Payan - Hillsborough CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07H 21/04

US Classification:

536 243, 536 2433

Abstract:

The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.

US Patent:

7265214, Sep 4, 2007

Filed:

Oct 19, 2001

Appl. No.:

10/029115

Inventors:

Ying Luo - Shanghai, CN
Simon Yu - Newark CA, US
Xiang Xu - South San Francisco CA, US
Cindy Leo - San Francisco CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07H 21/04
C12Q 1/68
C12N 5/02

US Classification:

536 231, 536 243, 536 2433, 536 245, 435 6, 435 911, 435325

Abstract:

The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

US Patent:

7300780, Nov 27, 2007

Filed:

Oct 21, 2002

Appl. No.:

10/493164

Inventors:

Cindy Leo - San Francisco CA, US
Ying Luo - Shanghai, CN
Xiang Xu - South San Francisco CA, US
Simon Yu - Newark CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 9/12
C07K 1/00

US Classification:

435194, 530350

Abstract:

The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

US Patent:

7863222, Jan 4, 2011

Filed:

Aug 1, 2008

Appl. No.:

12/221325

Inventors:

Donald G. Payan - Hillsborough CA, US
Mary Shen - Newark CA, US
Simon Yu - Newark CA, US
Todd M. Kinsella - Redwood City CA, US
Yasumichi Hitoshi - Mountain View CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C40B 50/06
C40B 40/08
C40B 30/06
C40B 40/02
C12P 19/34
A61K 49/12

US Classification:

506 26, 435 912, 506 17, 506 10

Abstract:

As noted above, certain aspects of this disclosure relate to a library of nucleic acid vectors, as well as a method for making the same. In certain embodiments, the library of nucleic acid vectors comprises: a plurality of nucleic acid molecules of the following formula: S—R—Swherein, in each nucleic acid of the plurality: Sand Sare each at least 15 nucleotides in length; Sand Sare complementary to each other along their entire length; either Sor Sis complementary along its entire length to a sequence in eukaryotic mRNA; and R is a six base recognition site for a restriction endonuclease; and wherein Sand Svary in nucleotide sequence between different members of the plurality. A method for amplifying a circular nucleic acid is also provided.

US Patent:

20020086778, Jul 4, 2002

Filed:

Dec 28, 2000

Appl. No.:

09/749060

Inventors:

Simon Yu - Oakland CA, US

International Classification:

A63B021/008

US Classification:

482/112000

Abstract:

An exercise device comprising a pneumatic hand pump with a valve in the exhaust port. The hand pump is pivotally attached to a folding metal chair or, in an alternate embodiment, to an elongated step board for easy use and storage and provides exercise and muscle toning when pumped against a strong force caused by a nearly closed valve in the exhaust port.

US Patent:

20080108098, May 8, 2008

Filed:

Oct 4, 2007

Appl. No.:

11/867504

Inventors:

Cindy Leo - San Francisco CA, US
Ying Luo - Pudong New Area, CN
Xiang Xu - South San Francisco CA, US
Simon Yu - Newark CA, US

Assignee:

Rigel Pharmaceuticals, Incorporated - South San Francisco CA

International Classification:

C12Q 1/48

US Classification:

435015000

Abstract:

The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.

US Patent:

20210299311, Sep 30, 2021

Filed:

Aug 13, 2020

Appl. No.:

16/993139

Inventors:

Simon Siu-Chi Yu - Oakland CA, US

International Classification:

A61L 2/24
B64C 39/02
A01M 13/00
A41D 13/11
B08B 13/00
B08B 7/00
B08B 5/00
B08B 7/04
A61L 2/10
A61L 2/20

Abstract:

An autonomous drone operated remotely via wireless networks is instructed by its owner flying about in an unoccupied room to activate a system of selectable air and surface disinfection modules. An air purifier captures particles in ambient air and switches on an oscillating motion tubular shaped cage mounted with a plurality of Ultraviolet C spectrum, long range zoom and focusable lens LED projectors to disinfect virus and bacteria. A fan assisted forced air Ozone generator module speeds up disinfecting inconspicuous spots to destroy hidden viruses. Disinfection is completed after the half-life time of dispensed Ozone and an oxygen recovery module rapidly converts residual ozone still in air back to normal oxygen molecules enabling a shortened waiting time for occupants to return to the treated room. A negative ions module subsequently switches on to refresh the air.