Son T Le

US Patent:

20210088463, Mar 25, 2021

Filed:

Sep 23, 2020

Appl. No.:

17/029999

Inventors:

- Gaithersburg MD, US
Curt Andrew Richter - Olney MD, US
Son Truong Le - Germantown MD, US

International Classification:

G01N 27/12
G01N 33/483
A61B 5/145
A61B 5/00
A61K 38/16

Abstract:

A closed-loop controlled chemical apparatus includes: a compound sensor including: an analyte sensor and that: produces, by the analyte sensor, a voltage signal; a reference sensor in electrical communication with the analyte sensor; a transistor including a gate terminal such that a drain current of the transistor is maintained at a constant value and operated at an optimal transduction condition of peak sensitivity and minimum noise of the transistor; a feedback controller in electrical communication with the transistor and that: receives a transduction signal; determining a deviation of the transduction signal from a setpoint, the setpoint determined by transfer characteristics of the transistor; produces the feedback control signal that minimizes the deviation of the transduction signal from the based on a control model; and communicates the feedback control signal to the reference sensor for suppression of electrical noise fluctuations in the closed-loop controlled chemical apparatus.

US Patent:

20200264129, Aug 20, 2020

Filed:

May 6, 2020

Appl. No.:

16/867590

Inventors:

- Gaithersburg MD, US
Curt Andrew Richter - Olney MD, US
Son Truong Le - Germantown MD, US
John S. Suehle - Baltimore MD, US

International Classification:

G01N 27/414
B01L 3/00
H01L 29/10
G01N 27/62

Abstract:

A charge detector includes: a charge sensor that senses a charged analyte and produces a charge signal in response to contact with the charged analyte; a transducer in electrical communication with the charge sensor and that: receives the charge signal from the charge sensor, receives a feedback control signal; and produces a transduction signal in response to receipt of the charge signal and the feedback control signal; and a sensitivity controller in electrical communication with the transducer and that: receives the transduction signal from the transducer; produces the feedback control signal in response to receipt of the transduction signal from the transducer; and produces a charge readout in response to receipt of the transduction signal from the transducer.