Stacey Laurel Davis

US Patent:

7709008, May 4, 2010

Filed:

Apr 4, 2006

Appl. No.:

11/396565

Inventors:

Timothy J. Foster - Dublin, IE
Kirk McCrea - Houston TX, US
Magnus A. O. Hook - Houston TX, US
Stacey Davis - Houston TX, US
Deirdre Ni Eidhin - Dublin, IE
Orla Hartford - Meath, IE

Assignee:

The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin - Dublin
The Texas A & M University System - College Station TX

International Classification:

A61K 39/085
C07H 21/04
C12N 15/74
C12N 1/21
C07K 14/31

US Classification:

4242431, 435 693, 4352523, 435470, 530350, 536 237

Abstract:

Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as , including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided. Methods are also provided wherein antibodies that recognize the SdrG protein or its ligand binding A region are used to treat or prevent staphylococcal infection, and these methods can also be utilized to prevent the formation of infections on indwelling medical devices.

US Patent:

20040038327, Feb 26, 2004

Filed:

Jul 9, 2003

Appl. No.:

10/615383

Inventors:

Timothy Foster - Dublin, IE
Kirk McCrea - Houston TX, US
Magnus Hook - Houston TX, US
Stacey Davis - Houston TX, US
Deirdre Ni Eidhin - Dublin, IE
Orla Hartford - Meath, IE

International Classification:

G01N033/554
G01N033/569
C07K016/12

US Classification:

435/007320, 530/388400

Abstract:

Antibodies reactive with isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as . The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The antibodies are also useful for the diagnosis and treatment of coagulase-negative staphylococcal infections and may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.

US Patent:

20040141997, Jul 22, 2004

Filed:

Oct 21, 2003

Appl. No.:

10/690184

Inventors:

Timothy Foster - Dublin, IE
Kirk McCrea - Houston TX, US
Magnus Hook - Houston TX, US
Stacey Davis - Houston TX, US
Deirdre Ni Eidhin - Dublin, IE
Orla Hartford - Duleek, IE

International Classification:

A61K048/00
A61K039/02

US Classification:

424/190100, 514/044000

Abstract:

Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as , including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided. Methods are also provided wherein antibodies that recognize the SdrG protein or its ligand binding A region are used to treat or prevent staphylococcal infection, and these methods can also be utilized to prevent the formation of infections on indwelling medical devices.

US Patent:

20040142348, Jul 22, 2004

Filed:

Oct 21, 2003

Appl. No.:

10/689082

Inventors:

Timothy Foster - Dublin, IE
Kirk McCrea - Houston TX, US
Magnus Hook - Houston TX, US
Stacey Davis - Houston TX, US
Deirdre Nieidhin - Dublin, IE
Orla Hartford - Meath, IE

International Classification:

C12Q001/68
C07H021/04
C07K014/31

US Classification:

435/006000, 435/069100, 435/252300, 435/320100, 530/350000, 536/023700

Abstract:

Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as , including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as . The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The proteins and polypetides may be useful in generating antibodies for the diagnosis and treatment of coagulase-negative staphylococcal infections.