Stacie M Halbert from 645 Dee Long Rd, Roxboro, NC 27574, age 55, Phone: (215)5130649

Protease Inhibitors
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US Patent:

20020049316, Apr 25, 2002
Filed:

Dec 17, 2001
Appl. No.:

10/022713
Inventors:

Stacie Halbert - Harleysville PA, US
Evelyne Michaud - Norristown PA, US
Scott Thompson - Phoenixville PA, US
Daniel Veber - Ambler PA, US
International Classification:

C07D417/02
C07D413/02
C 07D 4 3/02
US Classification:

540/603000, 544/060000, 544/137000, 544/139000, 544/133000, 544/238000, 544/333000, 544/387000, 544/369000, 544/370000, 546/209000, 546/210000, 546/141000, 546/153000
Abstract:

The present invention provides compounds of formula (I) which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia or malignancy; and metabolic bone disease therewith.

Carbohydrazide Protease Inhibitors
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US Patent:

62847775, Sep 4, 2001
Filed:

Apr 19, 2000
Appl. No.:

9/552616
Inventors:

Stacie Marie Halbert - Harleysville PA
Scott Kevin Thompson - Phoenixville PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 314409
A61K 314406
A61K 31444
C07D40112
C07D21330
US Classification:

514332
Abstract:

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, inducing osteoporosis; gingival disease including gingivitis and periodontists; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Protease Inhibitors
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US Patent:

63315424, Dec 18, 2001
Filed:

Apr 19, 2000
Appl. No.:

9/551968
Inventors:

Thomas Joseph Carr - Phoenixville PA
Renee Louise Desjarlais - St. Davids PA
Timothy Francis Gallagher - Harleysville PA
Stacie Marie Halbert - Harleysville PA
Hye-Ja Oh - Exton PA
Scott Kevin Thompson - Phoenixville PA
Daniel Frank Veber - Ambler PA
Dennis Shinji Yamashita - King of Prussia PA
Jack Hwekwo Yen - Malvern PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 315375
A61K 314409
C07D40112
C07D26530
US Classification:

5142378
Abstract:

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Compounds
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US Patent:

56840322, Nov 4, 1997
Filed:

Oct 5, 1995
Appl. No.:

8/539451
Inventors:

John Duncan Elliott - Wayne PA
Jack Dale Leber - Doylestown PA
Scott Kevin Thompson - Phoenixville PA
Stacie Marie Halbert - Harleysville PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 41405
US Classification:

514414
Abstract:

This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Protease Inhibitors
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US Patent:

62323423, May 15, 2001
Filed:

Jun 11, 1999
Appl. No.:

9/330451
Inventors:

Thomas Joseph Carr - Phoenixville PA
Renee Louise Desjarlais - St. Davids PA
Timothy Francis Gallagher - Harleysville PA
Stacie Marie Halbert - Harleysville PA
Hye-Ja Oh - Exton PA
Scott Kevin Thompson - Phoenixville PA
Daniel Frank Veber - Ambler PA
Dennis Shinji Yamashita - King of Prussia PA
Jack Hwekwo Yen - Malvern PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 31277
A61K 3118
C07C25550
C07C31118
US Classification:

514524
Abstract:

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Protease Inhibitors
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US Patent:

59984708, Dec 7, 1999
Filed:

Apr 13, 1999
Appl. No.:

9/290958
Inventors:

Stacie Marie Halbert - Harleysville PA
Scott Kevin Thompson - Phoenixville PA
Daniel Frank Veber - Ambler PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 3127
C07D27500
C07D27120
US Classification:

514482
Abstract:

Disclosed herein is a compound of the formula ##STR1## known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl) benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.

Carboxylic Acid Indole Inhibitors Of Chemokines
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US Patent:

59554924, Sep 21, 1999
Filed:

Sep 24, 1998
Appl. No.:

9/155220
Inventors:

Scott K. Thompson - Phoenixville PA
Stacie M. Halbert - Harleysville PA
Katherine L. Widdowson - King of Prussia PA
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 31405
C07C 6236
C07D20918
C07D40506
US Classification:

514419
Abstract:

This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).