Stacy Q Wright

US Patent:

6495657, Dec 17, 2002

Filed:

Oct 27, 2000

Appl. No.:

09/698619

Inventors:

William F. McDonald - Utica OH
Zhi Heng Huang - East Lansing MI
Stacy C. Wright - Lansing MI
Morris Danzig - Northbrook IL
Andrew C. Taylor - Ann Arbor MI

Assignee:

Michigan Biotechnology Institute - Lansing MI

International Classification:

C08G 6916

US Classification:

528310, 528312, 528313, 528315, 528316, 528318, 528322, 528335, 525 50, 525 541, 525 542, 525 5422, 128DIG 22, 4284111, 4284235, 4284744, 523112

Abstract:

A polyamide and a process for preparing the polyamide are disclosed. The process comprises reacting in a reaction mixture a monomer selected from unsaturated carboxylic acids, esters of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and mixtures thereof, and a first amine to form an intermediate reaction product in the reaction mixture, wherein the first amine is selected from RR NH, RNH , RR NH , RNH and mixtures thereof, wherein R and R can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, and reacting the intermediate reaction product and a second amine to form a polyamide, wherein the second amine is selected from R R NH, R NH , R R NH , R NH and mixtures thereof wherein R and R can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, wherein multiple of the R, R , R , and R are in vertically aligned spaced relationship along a backbone formed by the polyamide. In one version of the invention, the monomer is selected from maleic anhydride, maleic acid esters, and mixtures thereof. In another version of the invention, the first amine is an alkylamine, such as tetradecylamine, and the second amine is a polyalkylene polyamine, such as pentaethylenehexamine.

US Patent:

6797743, Sep 28, 2004

Filed:

May 7, 2001

Appl. No.:

09/850324

Inventors:

William F. McDonald - Utica OH
Stacy C. Wright - Flint MI
Andrew C. Taylor - Ann Arbor MI

Assignee:

Michigan Biotechnology Institute - Lansing MI

International Classification:

C08K 308

US Classification:

523122, 524403, 524413, 524434

Abstract:

A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from metals, metal alloys, metal salts, metal complexes and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one example embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A) P wherein A is hydroxyalkyl; and the metallic antimicrobial agent is selected from chelated silver ions, silver metal, chelated copper ions, copper metal, chelated zinc ions, zinc metal and mixtures thereof.

US Patent:

6939554, Sep 6, 2005

Filed:

Feb 5, 2002

Appl. No.:

10/068054

Inventors:

William F. McDonald - Utica OH, US
Zhi-Heng Huang - Walnut Creek CA, US
Stacy C. Wright - Columbus GA, US

Assignee:

Michigan Biotechnology Institute - Lansing MI

International Classification:

A01N025/00
A61K031/74

US Classification:

424405, 424 7808, 424 7831, 514772, 5147723

Abstract:

A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)P wherein A is hydroxyalkyl; and the antimicrobial agent is chlorhexidine, dimethylchlorophenol, cetyl pyridinium chloride, gentian violet, triclosan, thymol, iodine, and mixtures thereof.

US Patent:

20050043506, Feb 24, 2005

Filed:

Aug 24, 2004

Appl. No.:

10/924490

Inventors:

William McDonald - Utica OH, US
Zhi Huang - East Lansing MI, US
Stacy Wright - Lansing MI, US
Morris Danzig - Northbrook IL, US
Andrew Taylor - Ann Arbor MI, US

International Classification:

C08G069/08

US Classification:

528420000

Abstract:

A polyamide and a process for preparing the polyamide are disclosed. The process comprises reacting in a reaction mixture a monomer selected from unsaturated carboxylic acids, esters of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and mixtures thereof, and a first amine to form an intermediate reaction product in the reaction mixture, wherein the first amine is selected from RRNH, RNH, RRNH, RNH, and mixtures thereof, wherein R and R, can be the same or different and each contain between about and carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, and reacting the intermediate reaction product and a second amine to form a polyamide, wherein the second amine is selected from RRNH, RNH, RRNH, RNHand mixtures thereof wherein Rand Rcan be the same or different and each contain between about and carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, wherein multiple of the R, R, R, and Rare in vertically aligned spaced relationship along a backbone formed by the polyamide. In one version of the invention, the monomer is selected from maleic anhydride, maleic acid esters, and mixtures thereof. In another version of the invention, the first amine is an alkylamine, such as tetradecylamine, and the second amine is a polyalkylene polyamine, such as pentaethylenehexamine. In yet another version of the invention, the first amine and the second amine are olefinic or acetylenic amines, such as the reaction products of an alkyldiamine and an acetylenic carboxylic acid. The first amine and the second amine may be the same or different depending on the desired polyamide polymer structure.