Stanley A Lang

US Patent:

6335350, Jan 1, 2002

Filed:

Nov 22, 1999

Appl. No.:

09/447005

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan OHara - Norwood NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D21126

US Classification:

514331, 514378, 514408, 514587, 546229, 548247, 548568, 564 17

Abstract:

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

6380243, Apr 30, 2002

Filed:

Mar 12, 2001

Appl. No.:

09/804510

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan OHara - Norwood NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D30702

US Classification:

514438, 514461, 514361, 549 77, 549493, 548125

Abstract:

Compounds of the formula wherein A is heteroaryl; R -R are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R and R or R and R may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR , or is absent; G is aryl or heteroaryl; and X is a bond X is a bond, âNH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

6403617, Jun 11, 2002

Filed:

Sep 26, 2000

Appl. No.:

09/669535

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan OHara - Norwood NJ

Assignee:

American Home Products Corp. - Madison NJ

International Classification:

A61K 3144

US Classification:

514352, 514353, 546305, 546306, 546307

Abstract:

Compounds of the formula Useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, humanherpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

6407123, Jun 18, 2002

Filed:

Sep 26, 2000

Appl. No.:

09/670180

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan OHara - Norwood NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31443

US Classification:

514336, 514340, 5462687, 5462797, 546208, 546212

Abstract:

Compounds of the formula wherein R -R are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, âCN, âNO , âCO R , âCOR , âOR , âSR , âSOR , âSO R , âCONR R , âNR N(R R ), âN(R R ) or WâYâ(CH ) âZ ; or R and R or R and R , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R and R are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R and R , taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl.

US Patent:

6426355, Jul 30, 2002

Filed:

Sep 27, 2000

Appl. No.:

09/671486

Inventors:

Jonathan Bloom - Nyack NY
Kevin Curran - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Thomas Jones - New City NY
Stanley Lang - Carlsbad CA
Adma Ross - Suffern NY
Eugene A. Terefenko - Quakertown PA
Bryan OHara - Norwood NJ

Assignee:

American Home Products - Madison NJ

International Classification:

A61K 31433

US Classification:

514361, 548127, 548235, 5483335, 5483741, 548561, 549 72, 549487, 514374, 514400, 514406, 514423, 514448, 514461, 435 5

Abstract:

Compounds having the formula: wherein R -R , X and G are described herein and which are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

6462055, Oct 8, 2002

Filed:

Apr 30, 2001

Appl. No.:

09/845428

Inventors:

Jonathan Bloom - Nyack NY
Kevin Curran - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Emily Norton - Nyack NY
Adma Ross - Rockland NY
Bryan OHara - Norwood NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3147

US Classification:

514307, 514309, 514310, 514311, 514312, 514313, 514469, 514470, 546141, 546143, 546156, 546162, 549466, 549467, 549468

Abstract:

Compounds having the formula: wherein R -R are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, âCN, âNO , âCO R , âCOR , âOR , âSR , âSOR , âSO R , âCONR R , âNR N(R R ), âN(R R ) or W-Y-(CH ) -Z provided that at least one of R -R is not hydrogen; or R and R or R and R , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R and R are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R and R , taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR , or is absent; Y is â(CO)â or â(CO )â, or is absent; Z is alkyl of 1 to 4 carbon atoms, âCN, âCO R , COR , âCONR R , âOCOR , âNR COR , âOCONR , âOR , âSR , âSOR , âSO R , SR6N(R7R8), âN(R R ) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, âNH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

6555561, Apr 29, 2003

Filed:

Mar 15, 2002

Appl. No.:

10/099695

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan OHara - Norwood NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3144

US Classification:

514353, 546305, 546306, 546307, 546308, 5462681, 514352, 514336

Abstract:

This invention provides compounds of formula I having the structure Wherein substitutions at X, G, R , R , R , R , R are set forth in the specification.

US Patent:

7429667, Sep 30, 2008

Filed:

Jan 20, 2006

Appl. No.:

11/337243

Inventors:

Hassan Abdellaoui - Aliso Viejo CA, US
Robert Tam - Irvine CA, US
Huanming Chen - Irvine CA, US
Varaprasad Chamakura - Irvine CA, US
Dinesh Barawkar - Foothill Ranch CA, US
Andreas Maderna - Los Angeles CA, US
Zhi Hong - Irvine CA, US
Stanley Lang - Laguna Niguel CA, US

Assignee:

Ardea Biosciences, Inc. - San Diego CA

International Classification:

C07D 275/03
C07D 413/12
C07D 239/36
C07D 217/06
C07D 401/12
C07D 401/14
C07D 417/12

US Classification:

548213, 544145, 544298, 544367, 546145, 546171, 546209, 546256, 5462711

Abstract:

The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones.