Stephanie Lee

US Patent:

8170305, May 1, 2012

Filed:

Oct 19, 2007

Appl. No.:

11/975416

Inventors:

David H Laidlaw - Barrington RI, US
Song Zhang - Starkville MS, US
Stephanie Yat-Lin Lee - Needham MA, US
Stephen Correia - Cranston RI, US

Assignee:

Brown University - Providence RI

International Classification:

G01N 31/00

US Classification:

382128, 382154, 324309, 324312, 345419, 345424, 345442, 600410, 702 28

Abstract:

The exemplary embodiments of this invention relate at least in part to a method, apparatus and system to characterize white matter, such as for detecting a presence of a white matter impairment. An exemplary method to characterize white matter includes identifying at least one tract of interest (TOI) in the brain of a subject of interest, the tract of interest having a set of streamtubes representing white matter fibers; determining a set of quantitative tractography metrics associated with the tract of interest, the set of quantitative tractography metrics having a plurality of members; and comparing at least one member of the determined set of quantitative tractography metrics to a corresponding member of a reference set of quantitative tractography metrics, or comparison of one TOI in a single subject or group of subjects and other TOI in the same subject(s).

US Patent:

20160000413, Jan 7, 2016

Filed:

Jan 30, 2014

Appl. No.:

14/763778

Inventors:

- Boston MA, US
- Plymouth MI, US
David CHARGIN - Newton MA, US
Irving BIGIO - Chestnut Hill MA, US
Jennifer ROSEN - Wellesley MA, US
Aaron SIZE - Waltham MA, US
Stephanie LEE - Newton MA, US

International Classification:

A61B 10/02
A61B 5/00

Abstract:

Devices for performing fine-needle aspiration of tissue and methods of using the same are disclosed. The device includes a syringe including a fiber optic probe, a plunger, and a needle and a holder including a coupling mechanism, a first actuator, and a second actuator. The fiber optic probe is configured to move within a lumen of the needle and is guided into the needle by a fiber optic channel. The plunger is configured to create a vacuum in the needle.