Stephen John Bell

US Patent:

20110161257, Jun 30, 2011

Filed:

Dec 24, 2009

Appl. No.:

12/646989

Inventors:

Stephen S. Bell - Easton CT, US

International Classification:

G06N 5/02

US Classification:

706 11, 706 46

Abstract:

The present invention enables a user to obtain a prediction by easily interacting with a regression model, even if the number of combinations of input variables is relatively high. The results are presented in an easy-to-read format after a relatively small amount of time for processing. Interacting with the regression model includes receiving the values of one or more input variables, determining relevant combinations of the values, finding an individual prediction for each combination, and operating on the individual predictions to produce an output variable based on the individual predictions. The invention may be embodied as a method interacting with a regression model, a simulator assembly for interacting with a regression model, or a machine readable storage medium containing instructions associated with a regression model. A common spreadsheet utility may be utilized to embody the present invention.

US Patent:

56146183, Mar 25, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/484106

Inventors:

Bruce W. Stillman - Cold Spring Harbor NY
Stephen P. Bell - Cold Spring Harbor NY
Ryuji Kobayashi - Cold Spring Harbor NY
Jasper Rine - Moraga CA
Margit Foss - Durham NC
Francis J. McNally - Davis CA
Patricia Laurenson - San Francisco CA
Ira Herskowitz - Berkeley CA
Joachim Li - San Francisco CA
Kimberly Gavin - Cold Spring Harbor NY
Masumi Hidaka - Cold Spring Harbor NY

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
The Regents of the University of California - Oakland CA

International Classification:

C07H 2102
C07M 2104
C12Q 168
C12P 1934

US Classification:

536 231

Abstract:

Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.

US Patent:

55893414, Dec 31, 1996

Filed:

Jun 7, 1995

Appl. No.:

8/484105

Inventors:

Bruce W. Stillman - Cold Spring Harbor NY
Stephen P. Bell - Cold Spring Harbor NY
Ryuji Kobayashi - Cold Spring Harbor NY
Jasper Rine - Moraga CA
Margit Foss - Durham NC
Francis J. McNally - Davis CA
Patricia Laurenson - San Francisco CA
Ira Herskowitz - Berkeley CA
Joachim Li - San Francisco CA
Kimberly Gavin - Cold Spring Harbor NY
Masumi Hidaka - Cold Spring Harbor NY

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
The Regents of the University of California - Oakland CA

International Classification:

C12Q 168
C12N 1500
C12N 115
C07K 1439

US Classification:

435 6

Abstract:

Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.