Stephen C Doherty

US Patent:

20040013688, Jan 22, 2004

Filed:

Jul 3, 2003

Appl. No.:

10/613975

Inventors:

Donald Wise - Belmont MA, US
Debra Trantolo - Princeton MA, US
David Hile - Medford MA, US
Stephen Doherty - Newmarket NH, US

Assignee:

Cambridge Scientific, Inc.

International Classification:

A61K039/02
A61K039/002
A61K009/16
A61K009/50

US Classification:

424/190100, 424/191100, 424/490000

Abstract:

A bioadhesive mucosal delivery system is used in concert with systemic immunization to develop long-lasting immune responses correlative to protective immunity, especially for the prevention of infection with malaria, tularemia, anthrax, and First, the method provides controlled delivery of protective antigens, such as ODNs, to a mucosal site resulting in “priming” of mucosal receptors. Second, the method augments this mucosal prime with parenteral stimulation. In another embodiment, an intranasal vaccine is used in the treatment of tularemia and other bacterial and viral inhalation antigens. The use of CpG motifs in bacterial DNA allows for the activation of the innate immune response that is characterized by the production of immunostimulatory cytokines and polyreactive antibodies. The rapid response system limits the spread of the pathogen prior to specific immunity activation. The use of sustained mucosal exposure lowers the activation threshold of the innate immune system, allowing for a stronger and more rapid response to infection.

US Patent:

61419516, Nov 7, 2000

Filed:

Aug 18, 1998

Appl. No.:

9/135622

Inventors:

Leon Krukoski - Coventry CT
Nicola Laudadio - Vernon CT
Stephen P. Doherty - Unionville CT
Merrill L. Kratz - South Windsor CT

Assignee:

United Technologies Corporation - Hartford CT

International Classification:

F02C 1310

US Classification:

60 3902

Abstract:

A control system for operating a compressor bleed valve in a gas turbine engine to prevent compressor operation in surge region determines engine stability in response to a plurality of sensed engine parameters, and calculates and stores engine parameters to estimate compressor performance relative to a stability limit which is indicative of a surge operation. The control system further maintains a rolling average of the estimate of compressor performance for up to a predetermined number of engine flights. This rolling average of the estimate of compressor performance is indicative of engine usage and associated engine degradation. The control system determines a bias for the bleed valve in response to calculated engine parameters and adjusts the operation of the bleed valve in response to the compressor performance so as not to exceed the stability limit.