Stephen J Erickson

US Patent:

6416547, Jul 9, 2002

Filed:

Sep 20, 2000

Appl. No.:

09/665872

Inventors:

Stephen M. Erickson - Irvine CA
Leslie Pathmanaban - Lake Forest CA
Michael J. Numamoto - Irvine CA
Than Nguyen - Fullerton CA

Assignee:

Edwards Lifesciences Corporation - Irvine CA

International Classification:

A61F 224

US Classification:

623 211, 206438

Abstract:

A carrier for heart valves allows the removal of a heart valve from the carrier without manual manipulation. In addition, the carrier minimizes or substantially eliminates leaking of preserving fluid during transportation and storage. The carrier includes ajar, a rinse cage, and a holder to which a heart valve is attachable. The rinse cage includes a first engagement structure, for example, a channel, and the holder includes a second engagement structure, for example, a groove, complementary to the first engagement structure for releasably engaging therewith. A heart valve attached to the holder is disposed or suspended within the rinse cage when the engagement structures are engaged. A heart valve attached to the holder is protected not only when within the jar but also when removed from the jar. The holder has a socket for engaging with a surgical handle used to remove the valve from the jar for rinsing and implantation. The carrier may include apparatus for limiting rotation of the holder relative to the rinse cage and rotation of the rinse cage relative to the jar, which apparatus allows a surgical handle to be securely and firmly attached to the holder with essentially one hand and without removing the valve from the jar.

US Patent:

20130216997, Aug 22, 2013

Filed:

Feb 21, 2013

Appl. No.:

13/773339

Inventors:

Andrew J. Conrad - Malibu CA, US
Stephen Erickson - White Bear Township MN, US
Jose S. Gil - Winnetka CA, US
Ben Barrett Hopkins - Los Angeles CA, US

Assignee:

LABORATORY CORPORATION OF AMERICA HOLDINGS - Burlington NC

International Classification:

G01N 33/569
G01N 33/58

US Classification:

435 5, 435 732, 435 731

Abstract:

Disclosed are methods and systems for the isolation and detection of microbes from a sample. The use of binding agents for isolation of a microbe of interest from a sample are described. In certain embodiments, the methods use ribosome-based and/or bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. For example, embodiments of the present invention can achieve total amplification of at least 10,000 from a single infected cell.

US Patent:

20130217049, Aug 22, 2013

Filed:

Feb 21, 2013

Appl. No.:

13/772887

Inventors:

Andrew J. Conrad - Malibu CA, US
Stephen Erickson - White Bear Township MN, US
Ben Barrett Hopkins - Los Angeles CA, US

Assignee:

Laboratory Corporation of America Holdings - Burlington NC

International Classification:

G01N 33/543

US Classification:

435 794, 436501

Abstract:

Disclosed herein are methods and systems for the detection of an analyte of interest by an amplified assay. The method and systems of the invention utilize the high specificity of biomolecules that have been coupled to a solid support to further amplify a signal produced by the interaction of a binding agent with the analyte of interest as a means to detect low levels of the analyte of interest present in a sample. In certain embodiments, for immunochemical (for example, ELISA or RIA) or immunofluorescence assays in which a protein to be identified is bound directly or through capture antibodies to a passivated surface, amplification of 10,000-fold can be achieved.

US Patent:

20200140919, May 7, 2020

Filed:

Nov 5, 2019

Appl. No.:

16/674876

Inventors:

- Burlington NC, US
Jose S. Gil - Winnetka CA, US
Ben Barrett Hopkins - Sherman Oaks CA, US
Stephen Erickson - White Bear Township MN, US

Assignee:

Laboratory Corporation of America Holdings - Burlington NC

International Classification:

C12Q 1/66
G01N 33/569
G01N 33/58
C12N 15/86

Abstract:

Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.

US Patent:

20190218590, Jul 18, 2019

Filed:

Jan 14, 2019

Appl. No.:

16/247490

Inventors:

- Burlington NC, US
Jose S. Gil - Winnetka CA, US
Stephen Erickson - White Bear Township MN, US
Dwight Lyman Anderson - Minneapolis MN, US
Jessica Stach - St. Paul MN, US

International Classification:

C12Q 1/10
C12N 7/00
C12Q 1/6897

Abstract:

Disclosed herein are methods and systems for rapid detection of microorganisms such as spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as -specific bacteriophage, allows detection of a specific microorganism, such as spp. and an indicator signal may be amplified to optimize assay sensitivity.

US Patent:

20170131275, May 11, 2017

Filed:

Sep 13, 2016

Appl. No.:

15/263619

Inventors:

- Burlington NC, US
ANDREW J. CONRAD - Malibu CA, US
STEPHEN ERICKSON - White Bear Township MN, US
JOSE S. GIL - Winnetka CA, US
BEN BARRETT HOPKINS - Los Angeles CA, US

International Classification:

G01N 33/569
G01N 33/58
G01N 33/543

Abstract:

Disclosed are methods and systems for the isolation and detection of microbes from a sample. The use of binding agents for isolation of a microbe of interest from a sample are described. In certain embodiments, the methods use ribosome-based and/or bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. For example, embodiments of the present invention can achieve total amplification of at least 10,000 from a single infected cell.

US Patent:

20150233918, Aug 20, 2015

Filed:

Feb 18, 2015

Appl. No.:

14/625515

Inventors:

- Burlington NC, US
Ben Barrett Hopkins - Sherman Oaks CA, US
Jose S. Gil - Winnetka CA, US
Stephen Erickson - White Bear Township MN, US
Ekaterina Kovacheva - Gardena CA, US

Assignee:

Laboratory Corporation of America Holdings - Burlington NC

International Classification:

G01N 33/569

Abstract:

Disclosed herein are methods and systems for detection of a microorganism of interest using an amplification assay. The methods and systems utilize the specificity of binding agents, such as antibodies, to rapidly detect low levels of a specific microorganism present in a sample. In certain embodiments, antibodies are bound to a large number of the available binding sites on a microorganism.

US Patent:

20150218616, Aug 6, 2015

Filed:

Feb 18, 2015

Appl. No.:

14/625481

Inventors:

- Burlington NC, US
Jose S. Gil - Winnetka CA, US
Ben Barrett Hopkins - Sherman Oaks CA, US
Stephen Erickson - White Bear Township MN, US

Assignee:

Laboratory Corporation of America Holdings - Burlington NC

International Classification:

C12Q 1/66

Abstract:

Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.