Stephen W Hedrick

US Patent:

20120171292, Jul 5, 2012

Filed:

Jan 3, 2012

Appl. No.:

13/342889

Inventors:

Michael J. Sailor - La Jolla CA, US
Stephen M. Hedrick - Solana Beach CA, US
Lou Gu - La Jolla CA, US
Laura Ruff - San Diego CA, US
Zhengtao Qin - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 9/18
A61K 39/44
A61P 37/04
A61P 35/00
A61P 31/12
A61P 31/20
A61P 31/16
A61P 31/22
A61P 31/04
A61K 39/39
A61P 31/14
B82Y 20/00
B82Y 5/00

US Classification:

424490, 4241841, 4242771, 4241781, 4242041, 4242261, 4242271, 4242281, 4242091, 4242301, 4242331, 4242311, 4242111, 4242161, 4242151, 4242171, 4242121, 4242191, 4242081, 4242341, 977773, 977834, 977906

Abstract:

The disclosure relates to immunizing agents and devices.

US Patent:

20200080111, Mar 12, 2020

Filed:

Sep 19, 2016

Appl. No.:

15/761156

Inventors:

- Oakland CA, US
Valentino Gantz - San Diego CA, US
Stephen Hedrick - Solana Beach CA, US

International Classification:

C12N 15/90
A01K 67/033

Abstract:

Described herein are methods and compositions for autocatalytic genome editing and neutralizing autocatalytic genome editing. The autocatalytic genome editing may be based on genomic integration of a construct containing multiple elements or on a trans-complementation approach, in which genetic elements can be propagated separately. The disclosure provides a method for autocatalytic genome editing based on the CRISPR/CAS9 system, and methods of use thereof, in animals, humans, and plants for eliminating pathogens, targeting suppression of crop pests, strategies to combat virus (e.g., HIV) and other diseases (e.g., cancer) caused by retrovirus, as well as to generate homozygous mutations that are transmitted to nearly all offspring.