John E. Sims - Seattle WA David J. Cosman - Bainbridge Island WA Stephen D. Lupton - Seattle WA Bruce A. Mosley - Seattle WA Steven K. Dower - Redmond WA
Assignee:
Immunex Corporation - Seattle WA
International Classification:
C12N 1506
US Classification:
536 235, 536 231, 4353201, 435325, 435 691
Abstract:
Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
John E. Sims - Seattle WA David J. Cosman - Bainbridge Island WA Stephen D. Lupton - Seattle WA Bruce A. Mosley - Seattle WA Steven K. Dower - Redmond WA
Assignee:
Immunex Corporation - Seattle WA
International Classification:
C07K 14705
US Classification:
530350, 435 691, 536 235
Abstract:
Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
Aav Split-Packaging Genes And Cell Lines Comprising Such Genes For Use In The Production Of Recombinant Aav Vectors
James M. Allen - Seattle WA Anthony M. Stepan - Seattle WA Tineka J. Quinton - Seattle WA Stephen D. Lupton - Seattle WA
Assignee:
Targeted Genetics Corporation - Seattle WA
International Classification:
C12N 1587
US Classification:
435455, 435325, 435366, 435465, 4353201, 536 2372
Abstract:
The present invention provides AAV âsplit-packagingâ genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.
Hybrid Genes For Expression Of Stimulatory Factors In Activated T Cells
Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocyte is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.
John Sims - Seattle WA, US David Cosman - Bainbridge Island WA, US Stephen Lupton - Seattle WA, US Bruce Mosley - Seattle WA, US Steven Dower - Redmond WA, US
Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
Use Of Interleukin-7 To Stimulate Proliferation Of Hematopoietic Cell Precursors
Anthony E. Namen - Seattle WA Raymond G. Goodwin - Seattle WA Stephen D. Lupton - Seattle WA Diane Y. Mochizuki - Seattle WA
Assignee:
Sanofi-Synthelabo - Paris
International Classification:
A61K 3820
US Classification:
424 852
Abstract:
Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.
Soluble Type Ii Interleukin-1 Receptors And Methods
John E. Sims - Seattle WA David J. Cosman - Bainbridge Island WA Stephen D. Lupton - Seattle WA Bruce A. Mosley - Seattle WA Steven K. Dower - Redmond WA
Assignee:
Immunex Corporation - Seattle WA
International Classification:
A01N 3718
US Classification:
514 2
Abstract:
Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.
Anthony E. Namen - Seattle WA Raymond G. Goodwin - Seattle WA Stephen D. Lupton - Seattle WA Diane Y. Mochizuki - Seattle WA
Assignee:
Immunex Corporation - Seattle WA
International Classification:
C07K 1300 A61K 3702
US Classification:
530351
Abstract:
Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.