Stephen D Lupton

US Patent:

6504023, Jan 7, 2003

Filed:

Dec 13, 1999

Appl. No.:

09/461908

Inventors:

John E. Sims - Seattle WA
David J. Cosman - Bainbridge Island WA
Stephen D. Lupton - Seattle WA
Bruce A. Mosley - Seattle WA
Steven K. Dower - Redmond WA

Assignee:

Immunex Corporation - Seattle WA

International Classification:

C12N 1506

US Classification:

536 235, 536 231, 4353201, 435325, 435 691

Abstract:

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.

US Patent:

6521740, Feb 18, 2003

Filed:

May 16, 1995

Appl. No.:

08/441893

Inventors:

John E. Sims - Seattle WA
David J. Cosman - Bainbridge Island WA
Stephen D. Lupton - Seattle WA
Bruce A. Mosley - Seattle WA
Steven K. Dower - Redmond WA

Assignee:

Immunex Corporation - Seattle WA

International Classification:

C07K 14705

US Classification:

530350, 435 691, 536 235

Abstract:

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.

US Patent:

6541258, Apr 1, 2003

Filed:

Dec 12, 1997

Appl. No.:

08/981172

Inventors:

James M. Allen - Seattle WA
Anthony M. Stepan - Seattle WA
Tineka J. Quinton - Seattle WA
Stephen D. Lupton - Seattle WA

Assignee:

Targeted Genetics Corporation - Seattle WA

International Classification:

C12N 1587

US Classification:

435455, 435325, 435366, 435465, 4353201, 536 2372

Abstract:

The present invention provides AAV âsplit-packagingâ genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.

US Patent:

6593124, Jul 15, 2003

Filed:

Dec 16, 1998

Appl. No.:

09/213993

Inventors:

Stephen D. Lupton - Seattle WA
James M. Allen - Seattle WA
Andrew L. Feldhaus - Lynwood WA

Assignee:

Targeted Genetics Corporation - Seattle WA

International Classification:

C12N 121

US Classification:

4352523, 43525411, 435325, 4353201, 536 231, 536 234, 536 235, 536 2352, 536 241

Abstract:

Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocyte is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.

US Patent:

20030060616, Mar 27, 2003

Filed:

Jul 19, 2002

Appl. No.:

10/199209

Inventors:

John Sims - Seattle WA, US
David Cosman - Bainbridge Island WA, US
Stephen Lupton - Seattle WA, US
Bruce Mosley - Seattle WA, US
Steven Dower - Redmond WA, US

International Classification:

C12P021/02
C07K014/715
C12N005/06
C07H021/04

US Classification:

536/023500, 530/350000, 435/069100, 435/320100, 435/325000

Abstract:

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.

US Patent:

61563013, Dec 5, 2000

Filed:

May 12, 1999

Appl. No.:

9/310905

Inventors:

Anthony E. Namen - Seattle WA
Raymond G. Goodwin - Seattle WA
Stephen D. Lupton - Seattle WA
Diane Y. Mochizuki - Seattle WA

Assignee:

Sanofi-Synthelabo - Paris

International Classification:

A61K 3820

US Classification:

424 852

Abstract:

Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.

US Patent:

57670641, Jun 16, 1998

Filed:

May 16, 1995

Appl. No.:

8/442043

Inventors:

John E. Sims - Seattle WA
David J. Cosman - Bainbridge Island WA
Stephen D. Lupton - Seattle WA
Bruce A. Mosley - Seattle WA
Steven K. Dower - Redmond WA

Assignee:

Immunex Corporation - Seattle WA

International Classification:

A01N 3718

US Classification:

514 2

Abstract:

Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.

US Patent:

53289889, Jul 12, 1994

Filed:

Oct 6, 1992

Appl. No.:

7/957649

Inventors:

Anthony E. Namen - Seattle WA
Raymond G. Goodwin - Seattle WA
Stephen D. Lupton - Seattle WA
Diane Y. Mochizuki - Seattle WA

Assignee:

Immunex Corporation - Seattle WA

International Classification:

C07K 1300
A61K 3702

US Classification:

530351

Abstract:

Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.