Stephen J O'Brien

US Patent:

8182786, May 22, 2012

Filed:

Jun 12, 2006

Appl. No.:

11/451251

Inventors:

Stephen O'Brien - New York NY, US
Ming Yin - Los Alamos NM, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C01G 49/02

US Classification:

423632, 423633

Abstract:

The present invention describes methods for preparing high quality nanoparticles, i. e. , metal oxide based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents. The methods of the invention provide a simple and reproducible procedure for forming transition metal oxide nanocrystals, with yields over 80%. The highly crystalline and monodisperse nanocrystals are obtained directly without further size selection; particle size can be easily and fractionally increased by the methods. The resulting nanoparticles can exhibit magnetic and/or optical properties. These properties result from the methods used to prepare them. Also advantageously, the nanoparticles of this invention are well suited for use in a variety of industrial applications, including cosmetic and pharmaceutical formulations and compositions.

US Patent:

8367034, Feb 5, 2013

Filed:

Jun 3, 2005

Appl. No.:

11/628256

Inventors:

Stephen O'Brien - New York NY, US
Limin Huang - New York NY, US
Brian Edward White - Walton NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

D01F 9/127
B01J 21/08
B01J 23/88
B01J 23/75
B82B 1/00

US Classification:

4234473, 4234471, 4234476, 423445 B, 4234472, 977842, 977843, 502240, 502255, 502260, 502305, 502314, 502321

Abstract:

The present invention relates to cobalt and molybdenum doped mesoporous silica catalysts and methods for using the catalysts to making Single-Walled Carbon Nanotubes. The methods offer increased control over the orientation, length and diameter of the nanotubes produced.

US Patent:

20060140868, Jun 29, 2006

Filed:

Jun 20, 2005

Appl. No.:

11/156740

Inventors:

Stephanie Grancharov - New York NY, US
Stephen O'Brien - New York NY, US
Glenn Held - Pelham NY, US
Christopher Murray - Ossining NY, US

International Classification:

A61K 49/06
A61K 9/28

US Classification:

424009320, 427002140, 977930000

Abstract:

A method for the preparation of magnetic nanoparticles coated with a noble metal is described. The method includes providing a first mixture containing a first non-polar organic solvent and uncoated magnetic nanoparticles. The first mixture is mixed with a second mixture containing a second non-polar organic solvent and ions comprising the noble metal to form a third mixture. The third mixture is mixed with an organic ligand or a fourth mixture containing an organic ligand to form a fifth mixture. The fifth mixture is reacted with a sixth mixture containing a reducing agent to form a seventh mixture containing the monodispersed magnetic nanoparticles coated with the noble metal. The monodispersed magnetic coated nanoparticles may be separated from the seventh mixture by adding a polar organic solvent or a mixture of polar organic solvents in which the nanoparticles are insoluble.

US Patent:

20070059775, Mar 15, 2007

Filed:

Mar 29, 2006

Appl. No.:

11/394040

Inventors:

Kristi Hultman - New York NY, US
Amanda Willis - New York NY, US
Stephen O'Brien - New York NY, US
Truman Brown - New York NY, US
Paul Harris - New York NY, US
Nicholas Turro - Tenafly NJ, US
Adrienne Grzenda - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/567
G01N 33/551
G01N 33/53

US Classification:

435007200, 436524000, 977902000

Abstract:

The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the invention as a contrast agent to image specific cells or proteins in a subject using fluorescent and magnetic imaging techniques.

US Patent:

20090075035, Mar 19, 2009

Filed:

Oct 7, 2008

Appl. No.:

12/246758

Inventors:

Stephen O'Brien - New York NY, US
Limin Huang - Jersey City NJ, US
Brian Edward White - Walton NY, US
Samuel J. Wind - White Plains NY, US

International Classification:

B32B 3/10
B05D 1/32
C23C 16/26
H01L 21/283
B05D 5/12

US Classification:

4281951, 427282, 4272491, 427122, 438669, 257E21159, 977773, 977750

Abstract:

Apparatus and methods for forming the apparatus include nanoparticles, catalyst nanoparticles, carbon nanotubes generated from catalyst nanoparticles, and methods of fabrication of such nanoparticles and carbon nanotubes.

US Patent:

20090269269, Oct 29, 2009

Filed:

Oct 14, 2008

Appl. No.:

12/250893

Inventors:

Brian Edward White - Walton NY, US
Stephen O'Brien - New York NY, US

Assignee:

The Trustees of Columbia University in City of New York - New York NY

International Classification:

B01J 23/72
C01B 31/20

US Classification:

4234372, 502345, 502170, 502165, 502244, 502346, 502 60, 502318, 502324, 502331, 502304, 977902, 977777

Abstract:

The disclosed subject matter provides a copper oxide nanoparticle, a catalyst that includes the copper oxide nanoparticle, and methods of manufacturing and using the same. The catalyst can be used to catalyze a chemical reaction (e.g., oxidizing carbon monoxide (CO) to carbon dioxide (CO)).

US Patent:

20090297626, Dec 3, 2009

Filed:

Nov 5, 2007

Appl. No.:

11/982842

Inventors:

Stephen O'Brien - New York NY, US
Limin Huang - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 33/30
C01G 9/02
C01G 23/047
A61K 33/24
C09K 3/00
C07F 7/28
C07F 3/06

US Classification:

424642, 423622, 423610, 424641, 424617, 25218233, 556 54, 556130, 977773

Abstract:

The disclosed subject matter provides a method for preparing a metal oxide, the method includes (a) contacting a metal salt precursor with an alcohol to provide a metal oxide; and (b) removing the metal oxide from the alcohol.

US Patent:

20100135937, Jun 3, 2010

Filed:

Sep 24, 2009

Appl. No.:

12/566135

Inventors:

Stephen O'Brien - New York NY, US
Limin Huang - Jersey City NJ, US
Zhuoying Chen - Cambridge, GB
Ioannis Kymissis - New York NY, US
Zhang Jia - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 8/19
H01L 51/30
H01L 27/07
H01L 29/92
H01G 9/00
H01G 4/06
C09K 3/00
C01B 13/00
C01G 25/02
C01F 17/00
C01G 45/12
C01G 49/02
C01G 53/04
C01G 51/04
C01G 23/04
C01G 19/02
C01G 41/02
C01G 11/02
C01G 31/02
B32B 27/32
H01L 21/302
B05D 5/12

US Classification:

424 59, 257 40, 257532, 257300, 361502, 361524, 361311, 25218232, 25218233, 4235931, 42359412, 423263, 423599, 4235941, 4235943, 4235945, 423598, 4235949, 42359413, 42359414, 4235948, 428220, 438758, 4271263, 257E51049, 257E27034, 257E29342, 977773, 977762, 257E21214

Abstract:

Nanocrystalline forms of metal oxides, including binary metal oxide, perovskite type metal oxides, and complex metal oxides, including doped metal oxides, are provided. Methods of preparation of the nanocrystals are also provided. The nanocrystals, including uncapped and uncoated metal oxide nanocrystals, can be dispersed in a liquid to provide dispersions that are stable and do not precipitate over a period of time ranging from hours to months. Methods of preparation of the dispersions, and methods of use of the dispersions in forming films, are likewise provided. The films can include an organic, inorganic, or mixed organic/inorganic matrix. The films can be substantially free of all organic materials. The films can be used as coatings, or can be used as dielectric layers in a variety of electronics applications, for example as a dielectric material for an ultracapacitor, which can include a mesoporous material. Or the films can be used as a high-K dielectric in organic field-effect transistors. In various embodiments, a layered gate dielectric can include spin-cast (e.g., 8 nm-diameter) high-K BaTiOnanocrystals and parylene-C for pentacene OFETs.