Stephen W O'Connor

US Patent:

6919371, Jul 19, 2005

Filed:

Sep 17, 2003

Appl. No.:

10/666903

Inventors:

Stephen J. O'Connor - Guilford CT, US
Gaetan H. Ladouceur - Branford CT, US
William H. Bullock - Easton CT, US
Ann-Marie Campbell - Monroe CT, US
Miao Dai - Briarwood NY, US
Robert Dally - Indianapolis IN, US
Jacques Dumas - Bethany CT, US
Holia N. Hatoum-Mokdad - Hamden CT, US
Uday Khire - Hamden CT, US
Wendy Lee - Hamden CT, US
Qingjie Liu - Milford CT, US
Derek B. Lowe - Hamden CT, US
Steven R. Magnuson - Hamden CT, US
Ning Qi - Hamden CT, US
Tatiana E. Shelekhin - Ridgefield CT, US
Quanrong Shen - Fishers IN, US
Roger A. Smith - Madison CT, US
Ming Wang - Milford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K031/352
C07D311/58

US Classification:

514456, 5462821, 5462827, 549398, 549404, 514337

Abstract:

This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

US Patent:

6960601, Nov 1, 2005

Filed:

Sep 24, 2002

Appl. No.:

10/255049

Inventors:

Roger A. Smith - Madison CT, US
Stephen J. O'Connor - Guilford CT, US
Stephan-Nicholas Wirtz - Wuppertal, DE
Wai C. Wong - Hamden CT, US
Soongyu Choi - Trumbull CT, US
Harold C. E. Kluender - Trumbull CT, US
Ning Su - Hamden CT, US
Gan Wang - Wallingford CT, US
Furahi Achebe - West Haven CT, US
Shihong Ying - Orange CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

C07D233/90
A61K031/445

US Classification:

514326, 546210

Abstract:

This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

US Patent:

7071207, Jul 4, 2006

Filed:

Sep 24, 2002

Appl. No.:

10/487976

Inventors:

Roger A. Smith - Madison CT, US
Stephen J. O'Connor - Guilford CT, US
Wai C. Wong - Trumbull CT, US
Soongyu Choi - Skillman NJ, US
Harold C. Kluender - Trumbull CT, US
Jianmei Fan - Hamden CT, US
Zhonghua Zhang - Derby CT, US
Rico C. Lavoie - Chesire CT, US
Brent L. Podlogar - Flemington NJ, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 31/40
A61K 31/395
A61K 31/437
C07D 471/04
C07D 471/14

US Classification:

514300, 514318, 514333, 546113, 5462767, 546289

Abstract:

This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

US Patent:

7091228, Aug 15, 2006

Filed:

May 6, 2004

Appl. No.:

10/839833

Inventors:

Roger Smith - Madison CT, US
Ann-Marie Campbell - Monroe CT, US
Philip Coish - New Haven CT, US
Miao Dai - Briarwood NY, US
Susan Jenkins - Milford CT, US
Derek Lowe - Hamden CT, US
Stephen O'Connor - Guilford CT, US
Ning Su - Hamden CT, US
Gan Wang - Wallingford CT, US
Mingbao Zhang - Stamford CT, US
Lei Zhu - Milford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 31/428
A61K 31/426
C07D 277/82
C07D 277/42

US Classification:

514367, 514370, 548161, 548194, 548198

Abstract:

This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

US Patent:

7172897, Feb 6, 2007

Filed:

Nov 5, 2001

Appl. No.:

09/993342

Inventors:

Gary Blackburn - Glendora CA, US
Hau H. Duong - Los Angeles CA, US
Piotr Grodzinski - Chandler AZ, US
Jon Faiz Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Robert Pietri - Pasadena CA, US
Robert Henry Terbrueggen - Manhattan Beach CA, US
Frederic Zenhausern - Fountain Hills AZ, US
Gary T. Olsen - La Crescenta CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12M 1/34

US Classification:

4352872, 20440302, 20440303, 204406

Abstract:

The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

7312087, Dec 25, 2007

Filed:

Jan 11, 2001

Appl. No.:

09/760384

Inventors:

Hau H. Duong - Los Angeles CA, US
Gary Blackburn - Glendora CA, US
Jon F. Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Gary T. Olsen - La Cresenta CA, US
Robert Pietri - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q 1/68
G01N 15/06
G01N 33/00
G01N 33/48
G01N 35/00

US Classification:

436149, 422 50, 422 681, 422 8201, 422 8205, 436 43, 436 63, 436 64, 436 66, 436150, 205775, 205792, 2057935, 204164, 204461, 204193, 204194, 204400, 20440301, 20440302, 20440303, 204406, 204407

Abstract:

The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

7423156, Sep 9, 2008

Filed:

Jan 27, 2006

Appl. No.:

11/341197

Inventors:

Roger Smith - Madison CT, US
Ann-Marie Campbell - Monroe CT, US
Philip Coish - New Haven CT, US
Miao Dai - Briarwood NY, US
Susan Jenkins - Milford CT, US
Derek Lowe - Hamden CT, US
Stephen O'Connor - Guilford CT, US
Ning Su - Hamden CT, US
Gan Wang - Wallingford CT, US
Mingbao Zhang - Stamford CT, US
Lei Zhu - Milford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

C07D 277/42
C07D 277/62
C07D 263/34
C07D 263/58

US Classification:

548217, 548180, 548194, 548234

Abstract:

This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

US Patent:

7655129, Feb 2, 2010

Filed:

Apr 12, 2004

Appl. No.:

10/823503

Inventors:

Gary Blackburn - Glendora CA, US
Stephen E. Creager - Central SC, US
Scott Fraser - La Canada CA, US
Bruce D. Irvine - Glendora CA, US
Thomas J. Meade - Willmette IL, US
Stephen J. O'Connor - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US
Jost G. Vielmetter - Altadena CA, US
Thomas W. Welch - Pasadena CA, US

Assignee:

Osmetech Technology Inc. - Pasadena CA

International Classification:

G01N 27/327

US Classification:

2057775, 204452

Abstract:

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.